| Honorific-Prefix: | Hon. |
| Sumedha Jayasena | |
| Honorific-Suffix: | MP |
| Office: | Minister of Women's Affairs |
| Term Start: | 2000 |
| Term End: | 2001 |
| Office2: | Minister of Women Affairs & Social Welfare |
| Office3: | Minister of Child Development & Women's Empowerment |
| Office4: | Minister of Parliamentary Affairs |
| Term Start4: | 2010 |
| Term End4: | 12 January 2015 |
| Constituency Mp5: | Monaragala District |
| Parliament5: | Sri Lanka |
| Term Start5: | 1994 |
| Term End5: | 2020 |
| Birth Date: | 29 July 1952 |
| Nationality: | Sri Lankan |
| Party: | Sri Lanka Freedom Party |
| Otherparty: | United People's Freedom Alliance |
| Residence: | No. 114, Wellawaya Road, Monaragala |
Sumedha Gunawathie Jayasena (සුමේධා ගුණවතී ජයසේන) is a Sri Lankan politician who has served as a member of the Parliament of Sri Lanka and as a government cabinet minister. After the tragic murder of her husband, Jayasena De Silva, she was elected to take his place in Parliament.
Throughout her career, Sumedha G. Jayasena has held various cabinet ministerial positions and has been dedicated to serving her constituency of Monaragala. She played a role in the post-tsunami rehabilitation and rebuilding efforts in 2004 as the Minister of Social Services.