| Type: | combo |
| Component1: | Sumatriptan |
| Class1: | Triptan |
| Component2: | Naproxen |
| Class2: | Nonsteroidal anti-inflammatory drug (NSAID) |
| Tradename: | Treximet, Suvexx, others |
| Dailymedid: | Sumatriptan naproxen |
| Routes Of Administration: | By mouth |
| Atc Prefix: | N02 |
| Atc Suffix: | CC51 |
| Legal Ca: | Rx-only |
| Legal Ca Comment: | [1] |
| Legal Us: | Rx-only |
| Legal Us Comment: | [2] |
| Kegg: | D11577 |
Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. It is taken by mouth. It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine (5-HT) 1b/1d receptor agonist (triptan); and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Sumatriptan/naproxen is indicated for the acute treatment of migraine with or without aura in people twelve years of age and older.
A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.[3]
Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.[4]