Sultopride Explained

Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia.[1] [2] [3] It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist.[4] It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.[5]

Pharmacology

Sultopride!Site!Ki!Species!Ref
D21.6Human[6]
D33.8Human

Notes and References

  1. Book: Miguel Vela J, Buschmann H, Holenz J, Párraga A, Torrens A . Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application . Wiley-VCH . Weinheim . 2007 . 978-3-527-31058-6 .
  2. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000. 3-88763-075-0 .
  3. Book: European Drug Index . 4th . CRC Press . Boca Raton . 1998 . 3-7692-2114-1.
  4. Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, Nash NR, Olsson R, Davis RE, Hacksell U, Weiner DM, Brann MR . 6 . Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist . The Journal of Pharmacology and Experimental Therapeutics . 315 . 3 . 1278–1287 . December 2005 . 16135699 . 10.1124/jpet.105.092155 . 2247093 .
  5. Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V . Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics . European Journal of Pharmacology . 256 . 2 . 211–214 . April 1994 . 7914168 . 10.1016/0014-2999(94)90248-8 .
  6. Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, Nash NR, Olsson R, Davis RE, Hacksell U, Weiner DM, Brann MR . 6 . Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist . The Journal of Pharmacology and Experimental Therapeutics . 315 . 3 . 1278–1287 . December 2005 . 16135699 . 10.1124/jpet.105.092155 . 2247093 .

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