| Sultan Sharif Ali Secondary School | |
| Native Name: | Malay: Sekolah Menengah Sultan Sharif Ali |
| Postcode: | BC1515[1] |
| Pushpin Map: | Brunei |
| Pushpin Label Position: | none |
| District: | Cluster 4[2] |
| Grades: | Years 7-11 |
| Gender: | mixed |
Sultan Sharif Ali Secondary School (; abbreviated as SMSSA) is a government secondary school located in Salambigar in Brunei-Muara District, Brunei. The school provides five years of secondary education, leading up to GCE 'O' Level qualification.
The school is named after Sultan Sharif Ali, the third Sultan of Brunei who ruled in the 15th century.
Sultan Sharif Ali Secondary School began admitting students on 4 June 1990 as Sekolah Menengah Kampung Salambigar (Kampung Salambigar Secondary School).[3] The students previously studied at Pengiran Isteri Hajjah Mariam Secondary School, Sultan Omar Ali Saifuddien College, Sekolah Tinggi Perempuan Raja Isteri (Raja Isteri Girls' High School) and Sultan Muhammad Jamalul Alam Secondary School.
The school was eventually renamed as to its present name on 25 September 1992.