Sulphur Creek is a stream in eastern Iron County in the U.S. state of Missouri. It is a tributary of Crane Pond Creek.
The stream headwaters arise at 37.4203°N -90.6444°W and the confluence with Crane Pond Creek is at 37.3683°N -90.5828°W.The source area is in Clark National Forest and the stream flows south and southeast out of the forest area. It passes under Missouri Route C before its confluence with Crane Pond Creek south of the community of Minimum.[1]
Sulphur Creek was so named due to the occurrence of iron ore along the stream which settlers mistook for sulphur.[2]