| Sulphide Creek | |
| Pushpin Map: | Canada Southern Ontario |
| Pushpin Map Caption: | Location of the mouth of Sulphide Creek in southern Ontario |
| Subdivision Type1: | Country |
| Subdivision Name1: | Canada |
| Subdivision Type2: | Province |
| Subdivision Name2: | Ontario |
| Subdivision Type3: | Region |
| Subdivision Type4: | Counties |
| Subdivision Type5: | Municipalities |
| Source1: | Unnamed lake |
| Source1 Location: | Addington Highlands, Lennox and Addington County |
| Source1 Coordinates: | 44.5719°N -77.2028°W |
| Source1 Elevation: | 209m (686feet) |
| Mouth: | Stoco Lake |
| Mouth Location: | Tweed, Hastings County |
| Mouth Coordinates: | 44.4969°N -77.2831°W |
| Mouth Elevation: | 138m (453feet) |
| River System: | Great Lakes Basin |
Sulphide Creek is a creek in the Moira River and Lake Ontario drainage basins in Tweed, Hastings County and Addington Highlands, Lennox and Addington County in Ontario, Canada.
Sulphide Creek begins at an unnamed lake in Addington Highlands, Lennox and Addington County, at an elevation of 209m (686feet), about 600m (2,000feet) south of Ontario Highway 7 and 10km (10miles) east northeast of the community of Actinolite. It flows generally southwest almost immediately into Tweed, Hastings County, through a series of lakes and takes in several unnamed tributary creeks. It flows near the communities of Hungerford and Otter Creek to the community of Sulphide. It then heads south to its mouth at Cosy Cove, a bay on the north side of Stoco Lake and also the name of a community Cosy Cove on the bay, at an elevation of 138m (453feet). Stoco Lake flows via the Moira River into the Bay of Quinte in downtown Belleville.