Sulfiram Explained

Iupac Name:N,N,,-tetraethyldicarbonotrithioic diamide
Routes Of Administration:Topical
Bioavailability:Very low
Excretion:Renal, unchanged
Cas Number:95-05-6
Atcvet:yes
Atc Prefix:S02
Atc Suffix:QA02
Pubchem:7215
Chemspiderid:6945
Unii:1XHL4Q8P7Y
Kegg:D08545
C:10
H:20
N:2
S:3

Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Sulfiram is now rarely used, but,, is still available in Brazil, India, and South Africa (as monotherapy).[1]

Adverse effects

Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1] [4]

External links

Notes and References

  1. Book: Sweetman, Sean C. . Pesticides and repellents . Martindale: the complete drug reference . 36th . 2009 . 2050 . Pharmaceutical Press . London . 978-0-85369-840-1.
  2. Web site: [No authors listed] . Sarfiram - Bula . 2009 . Bulário de Remédios Comerciais . MedicinaNET . Portuguese . 2010-08-11.
  3. Copeman PW . Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram . . 1 . 5592 . 623–4 . March 1968 . 5637574 . 1985336 . 10.1136/bmj.1.5592.623.
  4. Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ . Photolysis of sulfiram: a mechanism for its disulfiram-like reaction . . 48 . 10 . 1917–25 . November 1994 . 7986203 . 10.1016/0006-2952(94)90590-8.