| succinate—CoA ligase (GDP-forming) | |
| Ec Number: | 6.2.1.4 |
| Cas Number: | 9014-36-2 |
| Go Code: | 0004776 |
In enzymology, a succinate—CoA ligase (GDP-forming) is an enzyme that catalyzes the chemical reaction
GTP + succinate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl coenzyme A synthetase. This enzyme participates in the citric acid cycle and propanoate metabolism.
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .