SucA RNA motif explained

SucA RNA motif
Symbol:sucA
Rfam:RF01070
Rna Type:Cis-reg
Tax Domain:Bacteria

The sucA RNA motif is a conserved RNA structure found in bacteria of the order Burkholderiales.[1] RNAs within this motif are always found in the presumed 5' UTR of sucA genes. sucA encodes a subunit of an enzyme that participates in the citric acid cycle by synthesizing succinyl-CoA from 2-oxoglutarate. A part of the conserved structure overlaps predicted Shine-Dalgarno sequences (involved in ribosome binding) of the downstream sucA genes. Because of the RNA motif's consistent gene association and a possible mechanism for sequestering the ribosome binding site, it was proposed that the sucA RNA motif corresponds to a cis-regulatory element. Its relatively complex secondary structure could indicate that it is a riboswitch. However, the function of this RNA motif remains unknown.

See also

Notes and References

  1. Weinberg Z, Barrick JE, Yao Z, etal . Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline . Nucleic Acids Res. . 35 . 14 . 4809–4819 . 2007 . 17621584 . 1950547 . 10.1093/nar/gkm487 .