| Subprefecture of Vila Mariana | |
| Settlement Type: | Subprefecture |
| Image Map1: | SaoPaulo Municip SaoPaulo.svg |
| Map Caption1: | Location of municipality of São Paulo within the State of São Paulo |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | Southeast |
| Subdivision Type2: | State |
| Subdivision Name2: | São Paulo |
| Subdivision Type3: | Municipality |
| Subdivision Name3: | São Paulo |
| Subdivision Type4: | Administrative Zone |
| Subdivision Name4: | South-Central |
| Parts Type: | Districts |
| Parts Style: | para |
| P1: | Vila Mariana |
| P2: | Saúde |
| P3: | Moema |
| Government Type: | Subprefecture |
| Leader Title: | Subprefect |
| Leader Name: | Manoel Antônio da Silva Araujo |
| Area Total Km2: | 26.87 |
| Population Total: | 294,627 |
| Population As Of: | 2008 |
| Blank Name: | HDI |
| Blank Info: | 0.952 – very high |
The Subprefecture of Vila Mariana is one of 32 subprefectures of the city of São Paulo, Brazil. It comprises three districts: Vila Mariana, Saúde, and Moema.[1]
The Ibirapuera Park is located in this subprefecture, as well as the main campus of Federal University of São Paulo and the Brazilian headquarters of IBM.