Stt3a, catalytic subunit of the oligosaccharyltransferase complex explained

STT3A, catalytic subunit of the oligosaccharyltransferase complex is a protein that in humans is encoded by the STT3A gene.^[1]

Function

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].

See also

• Oligosaccharyltransferase

Further reading

• Ruiz-Canada C, Kelleher DJ, Gilmore R . Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms . Cell . 136 . 2 . 272–83 . January 2009 . 19167329 . 2859625 . 10.1016/j.cell.2008.11.047 .
• Patel MR, Stadler ME, Deal AM, Kim HS, Shores CG, Zanation AM . STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates . Laryngoscope . 121 . 5 . 983–9 . May 2011 . 21520112 . 10.1002/lary.21736 . 206198313 .
• Sigstad E, Paus E, Bjøro T, Berner A, Grøholt KK, Jørgensen LH, Sobrinho-Simões M, Holm R, Warren DJ . The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors . Mod. Pathol. . 25 . 4 . 537–47 . April 2012 . 22157935 . 3318159 . 10.1038/modpathol.2011.188 .
• Shrimal S, Ng BG, Losfeld ME, Gilmore R, Freeze HH . Mutations in STT3A and STT3B cause two congenital disorders of glycosylation . Hum. Mol. Genet. . 22 . 22 . 4638–45 . November 2013 . 23842455 . 3888133 . 10.1093/hmg/ddt312 .
• Malaby HL, Kobertz WR . The middle X residue influences cotranslational N-glycosylation consensus site skipping . Biochemistry . 53 . 30 . 4884–93 . August 2014 . 25029371 . 4372077 . 10.1021/bi500681p .
• Ghosh A, Urquhart J, Daly S, Ferguson A, Scotcher D, Morris AA, Clayton-Smith J . Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A . J. Child Neurol. . 32 . 6 . 560–565 . May 2017 . 28424003 . 10.1177/0883073817696816 . 11435676 .

Notes and References

1. Web site: Entrez Gene: STT3A, catalytic subunit of the oligosaccharyltransferase complex. 2018-07-12.