STRN explained

Striatin is a protein that in humans is encoded by the STRN gene.^{[1] [2] [3]}

Interactions

STRN has been shown to interact with:

• CTTNBP2NL,
• CTTNBP2,
• FAM40A,
• MOBKL3,
• PDCD10,
• PPP2CA,
• PPP2R1A,
• RP6-213H19.1,
• STK24,^[4]
• STK25,^[5]
• STRN3,^[5] and
• TRAF3IP3.^[5]

Further reading

• Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC . WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A . The Journal of Biological Chemistry . 275 . 8 . 5257–63 . Feb 2000 . 10681496 . 3505218 . 10.1074/jbc.275.8.5257 . free .
• Gaillard S, Bartoli M, Castets F, Monneron A . Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1 . FEBS Letters . 508 . 1 . 49–52 . Nov 2001 . 11707266 . 10.1016/S0014-5793(01)03020-4 . 7887096 .
• Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y . A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues . Molecular Biology Reports . 28 . 4 . 185–91 . 2002 . 12153137 . 10.1023/A:1015726217890 . 9167130 .
• Hwang J, Pallas DC . STRIPAK complexes: structure, biological function, and involvement in human diseases . The International Journal of Biochemistry & Cell Biology . 47 . 118–48 . February 2014 . 24333164 . 3927685 . 10.1016/j.biocel.2013.11.021 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH . Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha . Proceedings of the National Academy of Sciences of the United States of America . 101 . 49 . 17126–31 . Dec 2004 . 15569929 . 534607 . 10.1073/pnas.0407492101 . 2004PNAS..10117126L . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F . Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain . Genomics . 51 . 1 . 136–9 . Jul 1998 . 9693043 . 10.1006/geno.1998.5342 .
2. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A . A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons . The Journal of Cell Biology . 134 . 4 . 1051–62 . Aug 1996 . 8769426 . 2120968 . 10.1083/jcb.134.4.1051 .
3. Web site: Entrez Gene: STRN striatin, calmodulin binding protein.
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 2007 . 3 . 89 . 17353931 . 1847948 . 10.1038/msb4100134 .
5. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Molecular & Cellular Proteomics . 8 . 1 . 157–71 . Jan 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .