Streptomyces tsukubensis explained

Streptomyces tsukubensis is a bacterium species from the genus of Streptomyces which has been isolated from soil in Ibaraki in Japan.^[1] Streptomyces tsukubensis produces the immunosuppressant tacrolimus.^{[1] [2]}

See also

• List of Streptomyces species

Further reading

• Chen. D.. Zhang. Q.. Zhang. Q.. Cen. P.. Xu. Z.. Liu. W.. Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems. Applied and Environmental Microbiology. 11 May 2012. 78. 15. 5093–5103. 10.1128/AEM.00450-12. 22582065. 3416438. 2012ApEnM..78.5093C .
• Barreiro. C. Prieto. C. Sola-Landa. A. Solera. E. Martínez-Castro. M. Pérez-Redondo. R. García-Estrada. C. Aparicio. JF. Fernández-Martínez. LT. Santos-Aberturas. J. Salehi-Najafabadi. Z. Rodríguez-García. A. Tauch. A. Martín. JF. Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).. Journal of Bacteriology. July 2012. 194. 14. 3756–7. 22740677. 10.1128/jb.00692-12. 3393489.
• Goranovič. Dušan. Blažič. Marko. Magdevska. Vasilka. Horvat. Jaka. Kuščer. Enej. Polak. Tomaž. Santos-Aberturas. Javier. Martínez-Castro. Miriam. Barreiro. Carlos. Mrak. Peter. Kopitar. Gregor. Kosec. Gregor. Fujs. Štefan. Martín. Juan F. Petković. Hrvoje. FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis. BMC Microbiology. 2012. 12. 1. 238. 10.1186/1471-2180-12-238. 23083511. 3551636 . free .
• Xia. Menglei. Huang. Di. Li. Shanshan. Wen. Jianping. Jia. Xiaoqiang. Chen. Yunlin. Enhanced FK506 production in by rational feeding strategies based on comparative metabolic profiling analysis. Biotechnology and Bioengineering. October 2013. 110. 10. 2717–2730. 10.1002/bit.24941. 23682004. 24059003.

External links

• Type strain of Streptomyces tsukubensis at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. [Deutsche Sammlung von Mikroorganismen und Zellkulturen]
2. Book: Oliver. Kayser. Grundwissen Pharmazeutische Biotechnologie. 2002. Vieweg+Teubner Verlag. Wiesbaden. 3-322-80124-1.