Streptomyces toxytricini explained

Streptomyces toxytricini is a Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreatic lipase inhibitor lipstatin,^[1] of which the antiobesity drug orlistat is a derivative.^[2]

Further reading

• Zhu. Tingheng. Wang. Lingfei. Wang. Weixia. Hu. Zhongce. Yu. Meilan. Wang. Kun. Cui. Zhifeng. Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium. Journal of General and Applied Microbiology. April 3, 2014. 60. 3. 106–111. 10.2323/jgam.60.106. 25008166. free.

External links

• Type strain of Streptomyces toxytricini at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H . Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity . J Antibiot (Tokyo) . 40 . 8 . 1081–5 . 1987 . 3680018 . 10.7164/antibiotics.40.1081. free .
2. Barbier P, Schneider F . Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin . Helvetica Chimica Acta . 70 . 1 . 196–202 . 1987 . 10.1002/hlca.19870700124.