Saccharopolyspora erythraea explained

Saccharopolyspora erythraea is a species of actinomycete bacteria within the genus Saccharopolyspora.

Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin.^[1] Cytochrome P450 eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B.^{[2] [3]}

Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis.^[4]

External links

• Type strain of Saccharopolyspora erythraea at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338 . 25 . 4 . 10.1038/nbt1297 . 17369815 . Nature Biotechnology . 447–453. 2007 . Oliynyk . Markiyan . Samborskyy . Markiyan . Lester . John B. . Mironenko . Tatiana . Scott . Nataliya . Dickens . Shilo . Haydock . Stephen F. . Leadlay . Peter F. . free .
2. Cupp-Vickery . JR . Poulos . TL . Structure of cytochrome P450eryF involved in erythromycin biosynthesis. . Nature Structural Biology . February 1995 . 2 . 2 . 144–53 . 10.1038/nsb0295-144 . 7749919. 22536232 .
3. Harris . DL . Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450 eryF . Journal of Inorganic Biochemistry . 20 September 2002 . 91 . 4 . 568–85 . 10.1016/s0162-0134(02)00477-4 . 12237223.
4. Liu. Wei-Bing. Shi. Yang. Yao. Li-Li. Zhou. Ying. Ye. Bang-Ce. 2013-01-01. Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea. PLOS ONE. 8. 11. e80676. 10.1371/journal.pone.0080676. 1932-6203. 3827479. 24236194. 2013PLoSO...880676L. free.