Streptococcus pseudopneumoniae explained
Streptococcus pseudopneumoniae is a gram-positive coccus that may cause pneumonia in humans.[1] [2] It was first described in 2004.[1] The organism is often mistaken for S. pneumoniae[1] and its clinical importance is as yet uncertain. It seems likely that most cases of S. pseudopneumoniae pneumonia are misdiagnosed as S. pneumoniae.[2]
The bacterium has a number of features that allows it to be distinguished from S. pneumoniae:[2]
- There is no pneumococcal capsule (and is therefore not typable).[2]
- It is not soluble in bile.[2]
- It is sensitive to optochin when incubated in ambient air, but appears resistant or to have indeterminate susceptibility when incubated in 5% carbon dioxide.[2]
- Commercial DNA probe hybridization tests (e.g., AccuProbe Streptococcus pneumoniae culture identification test; Gen-Probe, San Diego, CA) are falsely positive.[2]
Penicillin is the treatment of choice.[2] Most reported isolates are resistant to erythromycin and to tetracycline.
References
- Arbique JC, Poyart C, Trieu-Cuot P, etal . 2004. Accuracy of phenotypic and genotypic testing for identification of Streptococcus pneumoniae and description of Streptococcus pseudopneumoniae sp. nov.. J Clin Microbiol. 42. 10. 4686 - 4696. 10.1128/JCM.42.10.4686-4696.2004 . 15472328 . 522306.
- Keith ER, Podmore RG, Anderson TP, Murdoch DR . Characteristics of Streptococcus pseudopneumoniae isolated from purulent sputum samples. 2006. J Clin Microbiol. 44. 3. 923 - 927. 10.1128/JCM.44.3.923-927.2006 . 16517877 . 1393130.
Further reading
- Hideaki. Kawakami. Yuko. Nakane. Hiroko. Inuzuka. Tominori. Fukagawa. Toshihiro. Muto. Kiyofumi. Mochizuki. Kiyofumi. Okhusu. Hiroyuki. Suematsu. Yuka. Yamagishi. Hiroshige. Mikamo. Late-onset bleb-related endophthalmitis caused by Streptococcus pseudopneumoniae. International Ophthalmology. 2014. 34. 3. 643–646. 10.1007/s10792-013-9835-2. 23884602. 25826637.
- Shahinas. Dea. Thornton. Christina S.. Tamber. Gurdip Singh. Arya. Gitanjali. Wong. Andrew. Jamieson. Frances B.. Ma. Jennifer H.. Alexander. David C.. Low. Donald E.. Pillai. Dylan R.. Comparative Genomic Analyses of Streptococcus pseudopneumoniae Provide Insight into Virulence and Commensalism Dynamics. PLOS ONE. 2013. 8. 6. e65670. 10.1371/journal.pone.0065670. 23840352. 3686770. 2013PLoSO...865670S. free.
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