Stratum corneum chymotryptic enzyme explained

Stratum corneum chymotryptic enzyme
Ec Number:	3.4.21.117
Cas Number:	155215-90-0

Stratum corneum chymotryptic enzyme (kallikrein 7, SCCE, KLK7, PRSS6, hK7) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Cleavage of proteins with aromatic side chains in the P1 position

This enzyme has wide substrate specificity.

Notes and References

1. Skytt A, Strömqvist M, Egelrud T . Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme . Biochemical and Biophysical Research Communications . 211 . 2 . 586–9 . June 1995 . 7794273 . 10.1006/bbrc.1995.1853 .
2. Egelrud T . Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation . The Journal of Investigative Dermatology . 101 . 2 . 200–4 . August 1993 . 8393902 . 10.1111/1523-1747.ep12363804 .
3. Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T . Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase . The Journal of Biological Chemistry . 269 . 30 . 19420–6 . July 1994 . 8034709 .
4. Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP . The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation . Gene . 254 . 1-2 . 119–28 . August 2000 . 10974542 . 10.1016/S0378-1119(00)00280-8 .
5. Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R . Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis . The Journal of Investigative Dermatology . 123 . 1 . 62–6 . July 2004 . 15191543 . 10.1111/j.0022-202X.2004.22708.x . free .