Stratifin Explained

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.^{[1] [2]} The protein is named for its presence in stratified epithelial cells.

Interactions

Stratifin has been shown to interact with PLK4,^[3] ERRFI1,^[4] MARK3,^{[3] [4]} JUB^[4] and YWHAG.^[4]

Further reading

• Hermeking H . Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions . The Journal of Investigative Dermatology . 124 . 1 . ix-x . January 2005 . 15654940 . 10.1111/j.0022-202X.2004.23534.x . free .
• Mhawech P . 14-3-3 proteins--an update . Cell Research . 15 . 4 . 228–36 . April 2005 . 15857577 . 10.1038/sj.cr.7290291 . free .
• Lodygin D, Hermeking H . The role of epigenetic inactivation of 14-3-3sigma in human cancer . Cell Research . 15 . 4 . 237–46 . April 2005 . 15857578 . 10.1038/sj.cr.7290292 . free .
• Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J . Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes . Electrophoresis . 13 . 12 . 960–9 . December 1992 . 1286667 . 10.1002/elps.11501301199 . 41855774 .
• Prasad GL, Valverius EM, McDuffie E, Cooper HL . Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells . Cell Growth & Differentiation . 3 . 8 . 507–13 . August 1992 . 1390337 .
• Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B . 14-3-3sigma is a p53-regulated inhibitor of G2/M progression . Molecular Cell . 1 . 1 . 3–11 . December 1997 . 9659898 . 10.1016/S1097-2765(00)80002-7 . free .
• Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B . 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage . Nature . 401 . 6753 . 616–20 . October 1999 . 10524633 . 10.1038/44188 . 1999Natur.401..616C . 4413753 .
• Laronga C, Yang HY, Neal C, Lee MH . Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression . The Journal of Biological Chemistry . 275 . 30 . 23106–12 . July 2000 . 10767298 . 10.1074/jbc.M905616199 . free.
• Samuel T, Weber HO, Rauch P, Verdoodt B, Eppel JT, McShea A, Hermeking H, Funk JO . The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax . The Journal of Biological Chemistry . 276 . 48 . 45201–6 . November 2001 . 11574543 . 10.1074/jbc.M106427200 . free .
• Johnson BA, Stehn JR, Yaffe MB, Blackwell TK . Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms . The Journal of Biological Chemistry . 277 . 20 . 18029–36 . May 2002 . 11886850 . 10.1074/jbc.M110465200 . free .
• Tian H, Faje AT, Lee SL, Jorgensen TJ . Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways . Neoplasia . 4 . 2 . 171–80 . 2002 . 11896572 . 1550321 . 10.1038/sj.neo.7900219.
• Ku NO, Michie S, Resurreccion EZ, Broome RL, Omary MB . Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression . Proceedings of the National Academy of Sciences of the United States of America . 99 . 7 . 4373–8 . April 2002 . 11917136 . 123655 . 10.1073/pnas.072624299 . 2002PNAS...99.4373K . free .
• Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S . Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth . Nature . 417 . 6891 . 871–5 . June 2002 . 12075357 . 10.1038/nature00826 . 2002Natur.417..871U . 4348545 .
• Liu MY, Cai S, Espejo A, Bedford MT, Walker CL . 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s) . Cancer Research . 62 . 22 . 6475–80 . November 2002 . 12438239 .
• Bhatia K, Siraj AK, Hussain A, Bu R, Gutiérrez MI . The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells . Cancer Epidemiology, Biomarkers & Prevention . 12 . 2 . 165–9 . February 2003 . 12582028 .
• Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y, Chrousos GP . Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway . The Journal of Biological Chemistry . 278 . 28 . 25651–6 . July 2003 . 12730237 . 10.1074/jbc.M302818200 . free .
• Nakajima T, Shimooka H, Weixa P, Segawa A, Motegi A, Jian Z, Masuda N, Ide M, Sano T, Oyama T, Tsukagoshi H, Hamanaka K, Maeda M . Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage . Pathology International . 53 . 6 . 353–60 . June 2003 . 12787309 . 10.1046/j.1440-1827.2003.01481.x . 24822056 .
• Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U . Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437 . The Journal of Biological Chemistry . 278 . 35 . 33422–35 . August 2003 . 12816952 . 10.1074/jbc.M303173200 . free .

Notes and References

1. Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE . Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway . Journal of Molecular Biology . 231 . 4 . 982–98 . June 1993 . 8515476 . 10.1006/jmbi.1993.1346 .
2. Web site: Entrez Gene: SFN stratifin.
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Molecular & Cellular Proteomics . 4 . 6 . 785–95 . June 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .