Stratifin Explained

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.[1] [2] The protein is named for its presence in stratified epithelial cells.

Interactions

Stratifin has been shown to interact with PLK4,[3] ERRFI1,[4] MARK3,[3] [4] JUB[4] and YWHAG.[4]

Further reading

Notes and References

  1. Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE . Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway . Journal of Molecular Biology . 231 . 4 . 982–98 . June 1993 . 8515476 . 10.1006/jmbi.1993.1346 .
  2. Web site: Entrez Gene: SFN stratifin.
  3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
  4. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Molecular & Cellular Proteomics . 4 . 6 . 785–95 . June 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .