| Country: | ITA |
| Type: | SS |
| Route: | 115 |
| Maint: | ANAS |
| E-Road: | E45 |
| Map: | SS 115 percorso.png |
| Length Km: | 383 |
| Junction: | Autostrada A18 Autostrada A29 |
| Terminus A: | Trapani |
| Terminus B: | Syracuse |
| Cities: | Trapani, Agrigento, Gela, Ragusa, Syracuse |
The Strada statale 115 Sud Occidentale Sicula (SS115), is one of the major roads in Sicily, Italy. It is the major state highway running along the south coast and connects the towns of Trapani and Syracuse via Agrigento and Ragusa. It is 383 km long.It is a part of the E45 and E931 European routes.