Stictic acid explained

Stictic acid is an aromatic organic compound, a product of secondary metabolism in some species of lichens.[1]

Stictic acid is the subject of preliminary biomedical research. Stictic acid has cytotoxic and apoptotic effects in vitro.[2] Computational studies suggest stictic acid may also stimulate p53 reactivation.[3]

Notes and References

  1. 10.1021/np070145k . Stictic Acid Derivatives from the Lichen Usnea articulata and Their Antioxidant Activities . 2007 . Lohézic-Le Dévéhat . Françoise . Tomasi . Sophie . Elix . John A. . Bernard . Aurélie . Rouaud . Isabelle . Uriac . Philippe . Boustie . Joël . Journal of Natural Products . 70 . 7 . 1218–20 . 17629329.
  2. 15757498 . 2004 . Correché . ER . Enriz . RD . Piovano . M . Garbarino . J . Gómez-Lechón . MJ . Cytotoxic and apoptotic effects on hepatocytes of secondary metabolites obtained from lichens . 32 . 6 . 605–15 . Alternatives to Laboratory Animals. 10.1177/026119290403200611 . 31487885 . free .
  3. 10.1038/ncomms2361 . Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53 . 2013 . Wassman . Christopher D. . Baronio . Roberta . Demir . Özlem . Wallentine . Brad D. . Chen . Chiung-Kuang . Hall . Linda V. . Salehi . Faezeh . Lin . Da-Wei . Chung . Benjamin P. . Wesley Hatfield . G. . Richard Chamberlin . A. . Luecke . Hartmut . Lathrop . Richard H. . Kaiser . Peter . Amaro . Rommie E. . Nature Communications . 4 . 1407 . 23360998 . 3562459. 2013NatCo...4.1407W .

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