Sterubin Explained

Sterubin (7-methoxy-3',4',5-trihydroxyflavanone) is a bitter-masking flavanone extracted from Yerba Santa (Eriodictyon californicum) a plant growing in America.^[1]

Sterubin is one of the four flavanones identified by Symrise in this plant which elicit taste-modifying properties. The others are homoeriodictyol, its sodium salt, and eriodictyol.^[2]

Recent research has demonstrated some neuroprotective properties of Sterubin in vitro, but more research is needed before it can be considered a true drug candidate.^{[3] [4] [5]}

Notes and References

1. Patricia Kaminski and Richard Katz. Yerba Santa Eriodictyon californicum. Flower Essence Society.
2. Ley JP, Krammer G, Reinders G, Gatfield IL, Bertram HJ . Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae) . J. Agric. Food Chem. . 53 . 15 . 6061–6 . July 2005 . 16028996 . 10.1021/jf0505170 .
3. Wolfgang Fischer . Antonio Currais . Zhibin Liang . Antonio Pinto . Pamela Maher . Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa . Redox Biology . 21 . February 2019 . 101089 . 30594901 . 10.1016/j.redox.2018.101089 . 6309122 .
4. Zhibin Liang . Pamela Maher . Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin . Antioxidants . 11 . November 2022 . 11 . 2197 . 36358569 . 9686938 . 10.3390/antiox11112197 . free .
5. Batya Swift Yasgur. https://www.medscape.com/viewarticle/909499. (Paywalled) Medscape. February 2019.