Steroid-transporting ATPase explained

Steroid-transporting ATPase
Ec Number:	3.6.3.45

Steroid-transporting ATPase (pleiotropic-drug-resistance protein, PDR protein) is an enzyme with systematic name ATP phosphohydrolase (steroid-exporting).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

\rightleftharpoons ADP + phosphate + steroidout

This enzyme has two similar ATP-binding domains.

Notes and References

1. Prasad R, De Wergifosse P, Goffeau A, Balzi E . Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals . Current Genetics . 27 . 4 . 320–9 . March 1995 . 7614555 . 10.1007/BF00352101 .
2. Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M . bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily . Journal of Bacteriology . 177 . 6 . 1536–43 . March 1995 . 7883711 . 176770 .
3. Mahé Y, Lemoine Y, Kuchler K . The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo . The Journal of Biological Chemistry . 271 . 41 . 25167–72 . October 1996 . 8810273 . 10.1074/jbc.271.41.25167 . free .