Stepholidine Explained

(−)-Stepholidine is a protoberberine alkaloid found in the plant Stephania intermedia.

Stepholidine activity includes dual D₂ receptor antagonist and D₁ receptor agonist, and has shown antipsychotic activity in animal studies.^{[1] [2] [3] [4]}

Notes and References

1. Natesan S, Reckless GE, Barlow KB, etal . The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist . Psychopharmacology . 199 . 2 . 275–89 . August 2008 . 18521575 . 10.1007/s00213-008-1172-1 . 21653956 .
2. Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X . Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications . Curr. Med. Chem. . 14 . 28 . 2996–3002 . 2007 . 18220736 . 10.2174/092986707782794050.
3. Jin GZ, Zhu ZT, Fu Y . (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions . Trends Pharmacol. Sci. . 23 . 1 . 4–7 . January 2002 . 11804640 . 10.1016/S0165-6147(00)01929-5.
4. Fu W, Shen J, Luo X, etal . Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations . Biophys. J. . 93 . 5 . 1431–41 . September 2007 . 17468175 . 10.1529/biophysj.106.088500 . 1948031.