Stephen O'Rahilly explained

Honorific Prefix:Sir
Birth Date:1958 4, df=y
Birth Place:Dublin, Ireland
Citizenship:Ireland
United Kingdom
Alma Mater:University College Dublin (MB, BCh, BAO, MD)
Field:Bariatrics

Sir Stephen Patrick O'Rahilly (born 1 April 1958) is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders.[1] [2] [3] [4] [5] [6] [7] [8]

Early life and education

O'Rahilly was born on 1 April 1958 in Dublin, Ireland.[9] [10] He was educated at Beneavin De La Salle College in Finglas, Dublin. He studied medicine at University College Dublin, graduating in 1981 with Bachelor of Medicine, Bachelor of Surgery, Bachelor of Obstetrics (MB BCh BAO) degrees.[9] He later continued his studies and completed a Doctor of Medicine (MD) degree in 1987.

Research

O'Rahilly undertook research into Type 2 diabetes and insulin resistance at the University of Oxford and Harvard Medical School, before joining the University of Cambridge where he is a Professor of Clinical Biochemistry and Medicine, Director of the Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories,[11] Director of the MRC Metabolic Diseases Unit[11] and co-director of the Wellcome-MRC Institute of Metabolic Science. He is also the scientific Director of the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre, Associate Faculty at the Wellcome Trust Sanger Institute and honorary consultant physician at Addenbrooke's Hospital, Cambridge.[12] [13] [14] He is a professorial fellow of Pembroke College, Cambridge.

Notable Cambridge scientists with whom O'Rahilly has shared paper authorship include Krishna Chatterjee, David Dunger, Sadaf Farooqi, Nita Forouhi, Antonio Vidal-Puig, Nick Wareham, and Giles Yeo.

Awards and honours

O'Rahilly was elected to the Academy of Medical Sciences in 1999, the Royal Society in 2003. His nomination reads: He was awarded the Heinrich Wieland Prize[15] in 2002, the InBev-Baillet Latour Health Prize in 2010[16] and the Debrecen Award for Molecular Medicine in 2014.[17] He delivered the 2016 Harveian Oration[18] at the Royal College of Physicians of London.

O'Rahilly was knighted in the 2013 Birthday Honours for services to medical research.[19]

In 2017, he became a member of the Royal Irish Academy.[20] In 2018, he was made an Honorary Doctor of RCSI University of Medicine and Health Sciences in Dublin.[21]

In 2019, O'Rahilly was elected as an Honorary Fellow of the Learned Society of Wales (LSW).[22] He was also awarded the Banting Medal for his contributions towards diabetes research by the American Diabetes Association in the same year.[23]

O'Rahilly was awarded the Croonian Medal in 2011 by the Royal College of Physicians. He was awarded it again, by the Royal Society in 2022, this time jointly with Sadaf Farooqi and they presented their lecture[24] at the Royal Society in 2022.

In 2023, O'Rahilly was awarded the OU Health Harold Hamm International Prize for Biomedical Research in Diabetes for his outstanding research into the link between obesity and Type 2 diabetes.[25]

Personal life

O’Rahilly lives in Cambridge, England with his wife, journalist Philippa Lamb, and his stepson Felix Lamb. He was married to Suzy Oakes from 1990 until her death in 2011.

He holds dual Irish and British citizenship.[26]

Notes and References

  1. Neill . U. S. . A conversation with Stephen O'Rahilly . 10.1172/JCI70726 . Journal of Clinical Investigation . 123 . 6 . 2335–2336 . 2013 . 23722908. 3668822 .
  2. Weston . K. . Translating metabolic biochemistry into the clinic: An interview with Steve O'Rahilly . 10.1242/dmm.007641 . 21357759 . 3046085 . Disease Models & Mechanisms . 4 . 2 . 141–144 . 2011 .
  3. Gerken . T. . Girard . C. A. . Tung . Y. -C. L. . Webby . C. J. . Saudek . V. . Hewitson . K. S. . Yeo . G. S. H. . McDonough . M. A. . Cunliffe . S. . McNeill . 10.1126/science.1151710 . L. A. . Galvanovskis . J. . Rorsman . P. . Patrik Rorsman. Robins . P. . Prieur . X. . Coll . A. P. . Ma . M. . Jovanovic . Z. . Farooqi . I. S. . Sadaf Farooqi. Sedgwick . B. . Barroso . I. . Lindahl . T. . Tomas Lindahl. Ponting . C. P. . Chris Ponting. Ashcroft . F. M. . Frances Ashcroft. O'Rahilly . S. . Stephen O'Rahilly. Schofield . C. J. . Christopher J. Schofield. The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase . Science . 318 . 5855 . 1469–1472 . 2007 . 17991826. 2668859 . 2007Sci...318.1469G .
  4. 10.1038/43185. 9202122. 1997Natur.387..903M. 1997. Nature. 387. 6636. 903–8. Montague . C. T. . Farooqi . I. S. . Sadaf Farooqi. Whitehead . J. P. . Soos . M. A. . Rau . H. . Wareham . N. J. . Sewter . C. P. . Digby . J. E. . Mohammed . S. N. . Hurst . J. A. . Cheetham . C. H. . Earley . A. R. . Barnett . A. H. . Prins . J. B. . Oʼrahilly. Stephen. Congenital leptin deficiency is associated with severe early-onset obesity in humans. 205032762. free .
  5. 10.1056/NEJMoa035322. TheGPR54Gene as a Regulator of Puberty. New England Journal of Medicine. 349. 17. 1614–27. 2003. Seminara . S. B. . Messager . S. . Chatzidaki . E. E. . Thresher . R. R. . Acierno . J. S. . Shagoury . J. K. . Bo-Abbas . Y. . Kuohung . W. . Schwinof . K. M. . Hendrick . A. G. . Zahn . D. . Dixon . J. . Kaiser . U. B. . Slaugenhaupt . S. A. . Gusella . J. F. . O'Rahilly . S. . Carlton . M. B. L. . Crowley . W. F. . Aparicio . S. A. J. R. . Colledge . W. H. . 14573733. free .
  6. 10.1056/NEJM199909163411204. Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency. New England Journal of Medicine. 341. 12. 879–84. 1999. Farooqi . I. S . Sadaf Farooqi . Jebb . S. A. . Langmack . G. . Lawrence . E. . Cheetham . C. H. . Prentice . A. M. . Hughes . I. A. . McCamish . M. A. . O'Rahilly . S. . 10486419. free .
  7. 10.1073/pnas.1408523111. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proceedings of the National Academy of Sciences. 111. 24. 8901–8906. 2014. Payne . F.. Lim . K.. Girousse . A.. Brown . R. J.. Kory . N.. Robbins . A.. Xue . Y.. Sleigh . A.. Cochran . E.. Adams . C.. Dev Borman . A.. Russel-Jones . D.. Gorden . P.. Semple . R. K.. Saudek . V.. O'Rahilly . S.. Walther . T. C.. Barroso . I.. Savage . D. B. . 24889630 . 4066527. 2014PNAS..111.8901P. free.
  8. Web site: https://web.archive.org/web/20140413082922/http://www.clbc.cam.ac.uk/SOR/orahilly.html. 2014-04-13. University of Cambridge. Professor Steve O'Rahilly, Head of Department and Professor of Clinical Biochemistry and Medicine.
  9. Ellen Ruppel Shell, Fat Genes, Discover Magazine, 1 May 2000
  10. Web site: O'Rahilly, Sir Stephen (Patrick), (born 1 April 1958), Professor of Clinical Biochemistry and Medicine (formerly Professor of Metabolic Medicine), Departments of Medicine and Clinical Biochemistry, since 1996, Head, Clinical Biochemistry Department, since 2002, and Director, Institute of Metabolic Science, Metabolic Research Laboratories, since 2007, University of Cambridge; Fellow of Pembroke College, Cambridge, since 2007; Hon. Consultant Physician, Addenbrooke's Hospital, since 1994; Director, MRC Metabolic Diseases Unit (formerly MRC Centre for Obesity and Related Metabolic Diseases), since 2007; Scientific Director, NIHR Cambridge Biomedical Research Centre, since 2010 . . Oxford University Press . 9 August 2023 . en . 1 December 2022.
  11. Web site: Stephen O'Rahilly, University of Cambridge Metabolic Research Laboratories. https://web.archive.org/web/20140614184726/http://www.mrl.ims.cam.ac.uk/staff/hod. 2014-06-14.
  12. Web site: NIHR Cambridge Biomedical Research Centre Web Site.
  13. 23712428. 3674708. 2013. Roberts. E. W.. Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine. 210. 6. 1137–51. Deonarine. A. Jones. J. O.. Denton. A. E.. Feig. C. Lyons. S. K.. Espeli. M. Kraman. M. McKenna. B. Wells. R. J.. Zhao. Q. Caballero. O. L.. Larder. R. Coll. A. P.. O'Rahilly. S. Stephen O'Rahilly. Brindle. K. M.. Kevin Brindle. Teichmann. S. A.. Sarah Teichmann. Tuveson. D. A.. Fearon. D. T.. Douglas Fearon. 10.1084/jem.20122344.
  14. 18454148. 2669167. 2008. Loos. R. J.. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics. 40. 6. 768–75. Lindgren. C. M.. Li. S. Wheeler. E. Zhao. J. H.. Prokopenko. I. Inouye. M. Freathy. R. M.. Attwood. A. P.. Beckmann. J. S.. Berndt. S. I.. Prostate. Lung. Jacobs. K. B.. Chanock. S. J.. Hayes. R. B.. Bergmann. S. Bennett. A. J.. Bingham. S. A.. Bochud. M. Brown. M. Cauchi. S. Connell. J. M.. Cooper. C. Smith. G. D.. Day. I. Dina. C. De. S. Dermitzakis. E. T.. Doney. A. S.. Elliott. K. S.. 29. 10.1038/ng.140.
  15. http://www.heinrich-wieland-preis.de/index/getnews/id/7 Heinrich Wieland Prize
  16. 10.1242/dmm.006080 . Professor Stephen O'Rahilly wins the 2010 InBev-Baillet Latour Prize . Disease Models & Mechanisms . 3 . 7–8 . 402 . 2010 . 20610691 . free .
  17. Web site: Debrecen Award for Molecular Medicine . University of Debrecen . 2015-01-07 . dead . https://web.archive.org/web/20141213044251/http://www.deoec.hu/info.aspx?sp=82&web_id= . 2014-12-13 .
  18. Web site: Harveian Oration and dinner 2016. Royal College of Physician. 27 June 2016 . 2016-11-28.
  19. https://www.bbc.co.uk/news/health-22905680 Stephen O'Rahilly knighted
  20. Web site: 18 New Members of the Royal Irish Academy . Royal Irish Academy . 26 May 2017 . 27 Nov 2021.
  21. News: RCSI celebrates graduation of 900 healthcare and research professionals. Royal College of Surgeons in Ireland. 15 November 2018.
  22. https://www.learnedsociety.wales/fellow/stephen-orahilly LSW Honorary Fellows
  23. https://professional.diabetes.org/content-page/2019-banting-medal-scientific-achievement-stephen-orahilly-md 2019 Banting Medal for Scientific Achievement - Stephen O'Rahilly, MD
  24. https://royalsociety.org/grants-schemes-awards/awards/croonian-lecture Croonian Medal and Lecture
  25. Web site: McIntosh . Kate . 2023-06-07 . 2023 OU Health Harold Hamm International Prize for Biomedical Research in Diabetes . 2024-01-09 . For staff . en.
  26. News: Irish research scientist to be knighted by Queen Elizabeth. The Irish Times. 15 June 2013. Dan. Keenan.

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