Stephen L. Hoffman Explained

Stephen L. Hoffman (born July 31, 1948) is an American physician-scientist, tropical medicine specialist and vaccinologist, who is the founder and chief executive and scientific officer of Sanaria Inc., a company dedicated to developing PfSPZ vaccines to prevent malaria.

Early life and education

Hoffman was raised initially in Belmar and subsequently in Ocean Township, Monmouth County, New Jersey.[1] He graduated from Asbury Park High School in 1966,[2] received a BA in political science from the University of Pennsylvania in 1970, an MD from Cornell University Medical College (now Weill Cornell Medicine) in 1975, and a Diploma in Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine in 1978.[3] Additionally in 1978, he completed a residency in Family Medicine at the University of California San Diego.[4] He is board certified in Family Medicine and received a Certificate of Knowledge in Clinical Tropical Medicine and Travelers Health in 1998, and a Doctor of Science (DSc), honoris causa from Monmouth University in 2006.[5]

Professional career

Work experience

After completing his residency in 1978, Hoffman was co-founder and director of the Tropical Medicine and Travelers clinic at University Hospital, University of California, San Diego, an adjunct clinical faculty member, and an emergency room physician. In 1980, Hoffman was commissioned as a medical officer in the United States Navy and stationed in Jakarta, Indonesia at the Naval Medical Research Unit Two-Jakarta Detachment where he was the director of the Department of Clinical Investigation and Epidemiology through 1984. His initial focus was on treatment of severe, typhoid fever. He proposed and studied an intervention, which reduced the typhoid fever death rate by more than 80 percent.[6] He also conducted research throughout the Indonesian archipelago on cholera, filariasis, and malaria.[7] In 1987, Hoffman returned to Bethesda, MD, and served as the director of the Malaria Program at the Naval Medical Research Institute (later Naval Medical Research Center) until 2001. Hoffman and his team worked on identifying the targets and mechanisms of protective immunity against malaria and malaria vaccine development. They were the first in the world to test a DNA vaccine in normal humans and demonstrate that DNA vaccines elicited killer T cell responses. Hoffman also led the team that sequenced the Plasmodium falciparum genome.[8]

After retiring from the Navy, Hoffman spent two years as senior vice president of biologics at Celera Genomics, the company that sequenced the human genome. Hoffman worked with utilizing human genomics and proteomics to develop immunotherapies and vaccines against cancer and to establish the potential for the field of personalized medicine. He also organized the sequencing of the genome of Anopheles gambiae.

In 2003 Hoffman founded Sanaria Inc. to develop whole sporozoite malaria vaccines and has since been the chief executive and scientific officer of Sanaria Inc.[9]

Contributions to science and technology

Hoffman has over 500 scientific publications. He has made major contributions in the following areas.

Selected publications

Awards and distinctions

Awards

Memberships

Personal life

Hoffman is married to B. Kim Lee Sim, PhD, a molecular biologist, who is the founder and president of Protein Potential LLC and executive vice president of Sanaria Inc.[43] They have three children (Alexander [JD],[44] Seth [MD],[45] and Benjamin [MD, PhD][46]).

Notes and References

  1. Mancuso, Donna. "'Cunning' parasite thwarts scientists' tries for malaria cure", Asbury Park Press, January 14, 1992. Accessed July 12, 2022, via Newspapers.com. "'We need new and better drugs to treat people, better methods of controlling mosquitoes and the infrastructure to deliver the technology,' said Hoffman, who was born in Belmar and grew up in Ocean Township."
  2. https://www.aphshalloffame.com/inductee/StephenLHoffman Stephen L. Hoffman
  3. Web site: COVID-19 Alumni Stories: Dr Stephen Hoffmann . 2022-03-24 . LSHTM . en.
  4. Hoffman. Stephen L.. 2002-07-01. Presidential address: The American Society of Tropical Medicine and Hygiene in the last half century: from apparent anachronism to international leader and innovator.. The American Journal of Tropical Medicine and Hygiene. EN. 67. 1. 1–7. 10.4269/ajtmh.2002.67.1. 12363050 . free.
  5. Web site: Hoffman. Stephen. 2006. Monmouth Calendar of Events. 2022-02-02. Monmouth.edu.
  6. Hoffman . S. L. . Punjabi . N. H. . Kumala . S. . Moechtar . M. A. . Pulungsih . S. P. . Rivai . A. R. . Rockhill . R. C. . Woodward . T. E. . Loedin . A. A. . 1984-01-12 . Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone . The New England Journal of Medicine . 310 . 2 . 82–88 . 10.1056/NEJM198401123100203 . 0028-4793 . 6361558.
  7. Web site: Dr. Stephen Hoffman. 2022-02-07. WCM Newsroom. en.
  8. Web site: Marine Biological Laboratory . 2022-02-07 . comm.archive.mbl.edu.
  9. Web site: SANARIA INC. SBIR.gov . 2022-03-10 . www.sbir.gov.
  10. Punjabi. N. H.. Hoffman. S. L.. Edman. D. C.. Sukri. N.. Laughlin. L. W.. Pulungsih. S. P.. Rivai. A. R.. Sututo. null. Moechtar. A.. Woodward. T. E.. August 1988. Treatment of severe typhoid fever in children with high dose dexamethasone. The Pediatric Infectious Disease Journal. 7. 8. 598–600. 10.1097/00006454-198808000-00002. 0891-3668. 3050856. free.
  11. Hoffman. Stephen L.. Isenbarger. Daniel. Long. Gary W.. Sedegah. Martha. Szarfman. Ana. Waters. Leslie. Hollingdale. Michael R.. Van Der Meide. Peter H.. Finbloom. David S.. Ballou. W. Ripley. 1989. Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes. Science. 244. 4908. 1078–1081. 10.1126/science.2524877 . 1704001 . 2524877 . 0036-8075.
  12. Malik. A.. Egan. J. E.. Houghten. R. A.. Sadoff. J. C.. Hoffman. S. L.. 1991-04-15. Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. Proceedings of the National Academy of Sciences of the United States of America. 88. 8. 3300–3304. 10.1073/pnas.88.8.3300. 0027-8424. 1707538. 51434 . free .
  13. Sedegah. M.. Jones. T. R.. Kaur. M.. Hedstrom. R.. Hobart. P.. Tine. J. A.. Hoffman. S. L.. 1998-06-23. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proceedings of the National Academy of Sciences of the United States of America. 95. 13. 7648–7653. 10.1073/pnas.95.13.7648. 0027-8424. 9636204. 22711 . free .
  14. Hoffman. Stephen L.. Subramanian. G. Mani. Collins. Frank H.. Venter. J. Craig. 2002-02-07. Plasmodium, human and Anopheles genomics and malaria. Nature. 415. 6872. 702–709. 10.1038/415702a. 0028-0836. 11832959. 4414185 . free.
  15. Hoffman. Stephen L.. Goh. Lucy M. L.. Luke. Thomas C.. Schneider. Imogene. Le. Thong P.. Doolan. Denise L.. Sacci. John. de la Vega. Patricia. Dowler. Megan. Paul. Chris. Gordon. Daniel M.. 2002-04-15. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. The Journal of Infectious Diseases. 185. 8. 1155–1164. 10.1086/339409. 0022-1899. 11930326. free.
  16. Hoffman . Stephen L. . Billingsley . Peter F. . James . Eric . Richman . Adam . Loyevsky . Mark . Li . Tao . Chakravarty . Sumana . Gunasekera . Anusha . Chattopadhyay . Rana . Li . Minglin . Stafford . Richard . January 2010 . Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria . Human Vaccines . en . 6 . 1 . 97–106 . 10.4161/hv.6.1.10396 . 19946222 . 1209024 . 1554-8600.
  17. Luke . Thomas C. . Hoffman . Stephen L. . November 2003 . Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine . The Journal of Experimental Biology . 206 . Pt 21 . 3803–3808 . 10.1242/jeb.00644 . 0022-0949 . 14506215. 24138914 .
  18. Hoffman. S. L.. Oster. C. N.. Plowe. C. V.. Woollett. G. R.. Beier. J. C.. Chulay. J. D.. Wirtz. R. A.. Hollingdale. M. R.. Mugambi. M.. 1987-08-07. Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. Science. 237. 4815. 639–642. 10.1126/science.3299709. 0036-8075. 3299709. 1987Sci...237..639H.
  19. Doolan. D. L.. Hoffman. S. L.. 2000-08-01. The complexity of protective immunity against liver-stage malaria. Journal of Immunology. 165. 3. 1453–1462. 10.4049/jimmunol.165.3.1453. 0022-1767. 10903750. 520874. free.
  20. Sedegah. M.. Hedstrom. R.. Hobart. P.. Hoffman. S. L.. 1994-10-11. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proceedings of the National Academy of Sciences of the United States of America. 91. 21. 9866–9870. 10.1073/pnas.91.21.9866. 0027-8424. 7937907. 44918. 1994PNAS...91.9866S. free.
  21. Wang. R.. Doolan. D. L.. Le. T. P.. Hedstrom. R. C.. Coonan. K. M.. Charoenvit. Y.. Jones. T. R.. Hobart. P.. Margalith. M.. Ng. J.. Weiss. W. R.. 1998-10-16. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 282. 5388. 476–480. 10.1126/science.282.5388.476. 0036-8075. 9774275. 1998Sci...282..476W.
  22. Gardner. M. J.. Tettelin. H.. Carucci. D. J.. Cummings. L. M.. Aravind. L.. Koonin. E. V.. Shallom. S.. Mason. T.. Yu. K.. Fujii. C.. Pederson. J.. 1998-11-06. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science. 282. 5391. 1126–1132. 10.1126/science.282.5391.1126. 0036-8075. 9804551.
  23. Holt. Robert A.. Subramanian. G. Mani. Halpern. Aaron. Sutton. Granger G.. Charlab. Rosane. Nusskern. Deborah R.. Wincker. Patrick. Clark. Andrew G.. Ribeiro. José M. C.. Wides. Ron. Salzberg. Steven L.. 2002-10-04. The genome sequence of the malaria mosquito Anopheles gambiae. Science. 298. 5591. 129–149. 10.1126/science.1076181. 1095-9203. 12364791. 2002Sci...298..129H. 4512225.
  24. Epstein. J. E.. Tewari. K.. Lyke. K. E.. Sim. B. K. L.. Billingsley. P. F.. Laurens. M. B.. Gunasekera. A.. Chakravarty. S.. James. E. R.. Sedegah. M.. Richman. A.. 2011-10-28. Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science. 334. 6055. 475–480. 10.1126/science.1211548. 1095-9203. 21903775. 2011Sci...334..475E. 206536528. free.
  25. Seder. Robert A.. Chang. Lee-Jah. Enama. Mary E.. Zephir. Kathryn L.. Sarwar. Uzma N.. Gordon. Ingelise J.. Holman. LaSonji A.. James. Eric R.. Billingsley. Peter F.. Gunasekera. Anusha. Richman. Adam. 2013-09-20. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science. 341. 6152. 1359–1365. 10.1126/science.1241800. 1095-9203. 23929949. 2013Sci...341.1359S. 22462258. free.
  26. Sissoko. Mahamadou S.. Healy. Sara A.. Katile. Abdoulaye. Omaswa. Freda. Zaidi. Irfan. Gabriel. Erin E.. Kamate. Bourama. Samake. Yacouba. Guindo. Merepen A.. Dolo. Amagana. Niangaly. Amadou. May 2017. Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial. The Lancet. Infectious Diseases. 17. 5. 498–509. 10.1016/S1473-3099(17)30104-4. 1474-4457. 6803168. 28216244.
  27. Mordmüller . Benjamin . Surat . Güzin . Lagler . Heimo . Chakravarty . Sumana . Ishizuka . Andrew S. . Lalremruata . Albert . Gmeiner . Markus . Campo . Joseph J. . Esen . Meral . Ruben . Adam J. . Held . Jana . 2017-02-23 . Sterile protection against human malaria by chemoattenuated PfSPZ vaccine . Nature . 542 . 7642 . 445–449 . 10.1038/nature21060 . 1476-4687 . 28199305 . 2017Natur.542..445M . 205253429. 10906480 .
  28. Mwakingwe-Omari. Agnes. Healy. Sara A.. Lane. Jacquelyn. Cook. David M.. Kalhori. Sahand. Wyatt. Charles. Kolluri. Aarti. Marte-Salcedo. Omely. Imeru. Alemush. Nason. Martha. Ding. Lei K.. July 2021. Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Nature. 595. 7866. 289–294. 10.1038/s41586-021-03684-z. 1476-4687. 34194041. 11127244 . 2021Natur.595..289M. 1721.1/142862 . 235696393. free.
  29. Web site: Medals -ASTMH. 2022-02-07. ASTMH.
  30. Web site: Stephen Hoffman Faculty Member Faculty Opinions. 2022-02-07. facultyopinions.com.
  31. Web site: Member Directory - Asbury Park High School Hall of Fame. 2022-02-07. www.aphshalloffame.com.
  32. Web site: Dr. Stephen L. Hoffman wins 2015 CEO of the year at the World Vaccine Congress, Vaccine Industry Excellence Awards – Sanaria. 2022-02-07. en-US.
  33. Web site: 2015-05-14. CORRECTING and REPLACING Tech Council of Maryland Names Winners of 27th Annual Industry Awards. 2022-02-07. www.businesswire.com. en.
  34. Web site: Leadership – Sanaria . 2022-02-03 . en-US.
  35. Web site: Sanaria's Dr. Stephen L. Hoffman won the Daily Record's Innovator of the Year Award – Sanaria . 2022-03-25 . en-US.
  36. Web site: ASTMH - Fellows of ASTMH (FASTMH) . 2022-02-07 . www.astmh.org.
  37. Web site: IDSA Home . 2022-03-24 . www.idsociety.org . en.
  38. Web site: The American Society for Clinical Investigation. 2022-02-07. en-US.
  39. Web site: Association of American Physicians. 2022-02-07. aap-online.org.
  40. Web site: American Academy of Microbiology - Fellow Directory. 2022-02-07. American Academy of Microbiology.
  41. Web site: Elected Fellows American Association for the Advancement of Science. 2022-02-07. www.aaas.org. en.
  42. Web site: ABFM . 2022-03-10 . portfolio.theabfm.org.
  43. Web site: Malaysian . Scientific . 2016-06-13 . AMA session with Dr. Betty Kim Lee Sim . 2022-07-20 . Scientific Malaysian Magazine . en-US.
  44. Web site: Alexander Hoffman . linkedin.com.
  45. Web site: Seth Ari Sim-Son Hoffman's Profile Stanford Profiles . 2022-07-21 . profiles.stanford.edu . en.
  46. Web site: Benjamin Hoffman Profile . University of California, San Francisco.