Stephanie Schorge Explained

Stephanie Schorge
Workplaces:University College London
Thesis Title:mRNA variants of the n-type Ca channel α₁B subunit : their distribution and functional impact on the mammalian nervous system
Thesis Url:https://www.worldcat.org/oclc/1328693979
Thesis Year:1999

Stephanie Schorge is a Professor of Neuroscience in the Department of Neuroscience, Physiology and Pharmacology at University College London. She is known for her research into mutations that cause neurological diseases.

Education and career

Schorge received her B.S. from Yale University in 1994. She obtained a Ph.D. in Neuroscience from Brown University[1] where she worked with Diane Lipscombe. Schorge has held postdoctoral positions at the Department of Pharmacology and the Institute of Neurology, both at the University College London.[2] She has had a fellowship from the Worshipful Company of Pewterers[3] and a university research fellowship from the Royal Society.[4] In 2018 Schorge moved to the UCL School of Pharmacy to become professor in translational neuroscience and director of the research department of pharmacology. In 2021 she became head of the Department of Neuroscience, Physiology and Pharmacology (NPP).[5] She was subsequently awarded the Sophia Jex-Blake Chair of Physiology.

Research

Schorge is known for her research in how mutations in ion channels can cause neurological disease and how manipulating ion channels can be used to treat disease. She has worked on RNA processing in voltage gated calcium channels,[6] [7] single channel biophysics of NMDA receptors.[8] [9] and investigated the functional impacts of mutations in ion channels that are linked to human neurological disorders, the channelopathies.[10] She has also examined the genetics and functions of mutations linked to epilepsy, particularly in sodium channels,[11] and researched gene therapy treatments for epilepsy.[12]

Selected publications

Notes and References

  1. Web site: ORCID . 2022-01-06 . orcid.org.
  2. Web site: Admin . ERUK . 2019-05-09 . Stephanie Schorge Epilepsy Research UK . 2022-01-06 . epilepsyresearch.org.uk . en-GB.
  3. Web site: Iris View Profile . 2021-12-30 . iris.ucl.ac.uk.
  4. Web site: Royal Society announces prestigious University Research Fellowships for 2010 Royal Society . 2023-04-09 . royalsociety.org.
  5. Web site: UCL. 2021-07-12. Prof Stephanie Schorge. 2022-01-06. UCL Division of Biosciences. en.
  6. Schorge . S. . Gupta . S. . Lin . Z. . McEnery . M. W. . Lipscombe . D. . 1999-09-02 . Calcium channel activation stabilizes a neuronal calcium channel mRNA . Nature Neuroscience . 2 . 9 . 785–790 . 10.1038/12153 . 1097-6256 . 10461216 . 11155519.
  7. Lin . Z. . Lin . Y. . Schorge . S. . Pan . J. Q. . Beierlein . M. . Lipscombe . D. . 1999-07-01 . Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons . The Journal of Neuroscience. 19 . 13 . 5322–5331 . 10.1523/JNEUROSCI.19-13-05322.1999 . 0270-6474 . 6782300 . 10377343.
  8. Schorge . Stephanie . Elenes . Sergio . Colquhoun . David . 2005-12-01 . Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits . The Journal of Physiology . 569 . Pt 2 . 395–418 . 10.1113/jphysiol.2005.095349 . 0022-3751 . 1464248 . 16223763.
  9. Schorge . Stephanie . Elenes . Sergio . Colquhoun . David . 2005 . Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits . The Journal of Physiology . en . 569 . 2 . 395–418 . 10.1113/jphysiol.2005.095349 . 1469-7793 . 1464248 . 16223763.
  10. Schorge . Stephanie . 2018-02-14 . Channelopathies go above and beyond the channels . Neuropharmacology . 132 . 1–2 . 10.1016/j.neuropharm.2018.02.011 . 1873-7064 . 29454019 . 3518363.
  11. Tate . Sarah K. . Depondt . Chantal . Sisodiya . Sanjay M. . Cavalleri . Gianpiero L. . Schorge . Stephanie . Soranzo . Nicole . Thom . Maria . Sen . Arjune . Shorvon . Simon D. . Sander . Josemir W. . Wood . Nicholas W. . 2005-04-12 . Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin . Proceedings of the National Academy of Sciences of the United States of America . 102 . 15 . 5507–5512 . 2005PNAS..102.5507T . 10.1073/pnas.0407346102 . 0027-8424 . 556232 . 15805193 . free.
  12. Wykes . Robert C. . Heeroma . Joost H. . Mantoan . Laura . Zheng . Kaiyu . MacDonald . Douglas C. . Deisseroth . Karl . Hashemi . Kevan S. . Walker . Matthew C. . Schorge . Stephanie . Kullmann . Dimitri M. . 2012-11-21 . Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy . Science Translational Medicine . EN . 4 . 161 . 161ra152 . 10.1126/scitranslmed.3004190 . 3605784 . 23147003.

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