Stefan Karlsson (professor) explained

Stefan Karlsson (born Iceland, 31 May 1950) is a Professor of Molecular Medicine and Gene Therapy at the Lund Stem Cell Center, in the Department of Laboratory Medicine, Lund University, Sweden.[1] He is recognized for significant contributions to the fields of gene therapy and hematopoietic stem cell biology and in 2009 was awarded the Tobias Prize[2] by The Royal Swedish Academy of Sciences.

Career

Karlsson's field of research is the regulation of hematopoietic stem cells and development of stem cell expansion protocols and gene therapy. He performed postdoctoral studies with Professor Arthur W. Nienhuis (1983-1986) at the National Heart Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH), Bethesda Maryland, where he received a Fogarty International Research Collaboration Award. He served as Chief of the Molecular and Medical Genetics Section, Developmental and Metabolic Neurology Branch (DMNB), National Institute for Neurological Disorders and Stroke (NINDS), NIH, 1988-1996. In 1995 he was recruited as a full professor to Lund University, Sweden, where he founded the Division of Molecular Medicine and Gene Therapy[3] and has been head of this division for twenty years.[4] He is also a founding and current member of the Lund Stem Cell Center,[5] since 2003, and director of the Hemato-Linné Strategic Research Environment[6] (2006-2016) funded through a 10-year Linnaeus grant from the Swedish Research Council.[7] Dr. Karlsson also holds a consultant physician position at Skåne University Hospital,[8] Sweden.

Research

Karlsson's early research focused on retroviral vector based gene correction of hematopoietic cells from monogenetic disorders, such as Gaucher’s disease[9] and hemoglobinopathies.[10] The results of these studies led to the first gene therapy clinical trial for the treatment of Gaucher’s disease (1995).[11] He has also developed lentiviral vectors for gene correction of hematopoietic stem cells,[12] and more recently developed preclinical gene therapy models for Gaucher’s disease[13] and Diamond Blackfan anemia.[14] An equal component of his research has been in the field of hematopoietic stem cell biology, where Dr. Karlsson focused on studying the mechanisms of hematopoietic stem cell expansion and maintenance with major contributions to understanding the role of Tgf-beta[15] and more recently Cripto.[16]

Selected awards and honors

Notes and References

  1. Web site: Lund University, Stem Cell Center, Sweden: Stefan Karlsson.
  2. Web site: Tobias laureates. The Royal Swedish Academy of Sciences. 2015-06-02. 2016-10-31. https://web.archive.org/web/20161031160439/http://www.kva.se/en/Prizes/Tobias-Prize/Laureates/. dead.
  3. Web site: Division of Molecular Medicine and Gene Therapy, Lund University, Sweden. 2015-05-13. 2017-09-10. https://web.archive.org/web/20170910201130/http://www.med.lu.se/plain/labmedlund/molecular_medicine_and_gene_therapy. dead.
  4. Web site: Symposium in Honor of Stefan Karlsson: Founder of Division of Molecular Medicine and Gene Therapy.
  5. Web site: Lund Stem Cell Center.
  6. Web site: Hemato-Linné Strategic Research Environment: Lund University, Sweden.
  7. Web site: Swedish Research Counsel: Hemato-Linné Environment coordinated by Stefan Karlsson.
  8. Web site: Skåne University Hospital.
  9. Fink. JK. Correll. PH. Perry. LK. Brady. RO. Karlsson. S. Correction of glucocerebrosidase deficiency after retroviral-mediated gene transfer into hematopoietic progenitor cells from patients with Gaucher disease.. Proceedings of the National Academy of Sciences of the United States of America. March 1990. 87. 6. 2334–8. 2315324. 10.1073/pnas.87.6.2334. 53681. free.
  10. Karlsson. S. Bodine. DM. Perry. L. Papayannopoulou. T. Nienhuis. AW. Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice.. Proceedings of the National Academy of Sciences of the United States of America. August 1988. 85. 16. 6062–6. 3413076. 10.1073/pnas.85.16.6062. 281905. free.
  11. Dunbar. CE. Kohn. DB. Schiffmann. R. Barton. NW. Nolta. JA. Esplin. JA. Pensiero. M. Long. Z. Lockey. C. Emmons. RV. Csik. S. Leitman. S. Krebs. CB. Carter. C. Brady. RO. Karlsson. S. Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation.. Human Gene Therapy. 20 November 1998. 9. 17. 2629–40. 9853529. 10.1089/hum.1998.9.17-2629.
  12. Woods. NB. Fahlman. C. Mikkola. H. Hamaguchi. I. Olsson. K. Zufferey. R. Jacobsen. SE. Trono. D. Karlsson. S. Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells.. Blood. 1 December 2000. 96. 12. 3725–33. 10.1182/blood.V96.12.3725.h8003725_3725_3733. 11090053.
  13. Enquist. IB. Nilsson. E. Ooka. A. Månsson. JE. Olsson. K. Ehinger. M. Brady. RO. Richter. J. Karlsson. S. Effective cell and gene therapy in a murine model of Gaucher disease.. Proceedings of the National Academy of Sciences of the United States of America. 12 September 2006. 103. 37. 13819–24. 16954197. 10.1073/pnas.0606016103. 1564262. free.
  14. Jaako. P. Flygare. J. Olsson. K. Quere. R. Ehinger. M. Henson. A. Ellis. S. Schambach. A. Baum. C. Richter. J. Larsson. J. Bryder. D. Karlsson. S. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.. Blood. 1 December 2011. 118. 23. 6087–96. 21989989. 10.1182/blood-2011-08-371963. free.
  15. Kulkarni. AB. Huh. CG. Becker. D. Geiser. A. Lyght. M. Flanders. KC. Roberts. AB. Sporn. MB. Ward. JM. Karlsson. S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.. Proceedings of the National Academy of Sciences of the United States of America. 15 January 1993. 90. 2. 770–4. 8421714. 10.1073/pnas.90.2.770. 45747. free.
  16. Miharada. K. Karlsson. G. Rehn. M. Rörby. E. Siva. K. Cammenga. J. Karlsson. S. Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.. Cell Stem Cell. 4 October 2011. 9. 4. 330–44. 21982233. 10.1016/j.stem.2011.07.016. free.
  17. Web site: Past Presidents of International Society for Experimental Hematology.
  18. Web site: Tobias Prize Laureates: The Royal Swedish Academy of Sciences. 2015-06-02. 2016-10-31. https://web.archive.org/web/20161031160439/http://www.kva.se/en/Prizes/Tobias-Prize/Laureates/. dead.
  19. Web site: Wallenberg Foundation: Excellence in Swedish Research awards 2014.

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