| State: | VA |
| Type: | VA |
| Route: | 45 |
| Length Mi: | 39.72 |
| Length Round: | 2 |
| Map: | VA 45 map.svg |
| Established: | 1928 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | in Farmville |
| Junction: | in Cumberland |
| Terminus B: | at Georges Tavern |
| Counties: | Prince Edward, Cumberland, Goochland |
| Previous Type: | VA |
| Previous Route: | 43 |
| Next Type: | VA |
| Next Route: | 46 |
State Route 45 (SR 45) is a primary state highway in the U.S. state of Virginia. The state highway runs 39.72miles from the junction of U.S. Route 15 Business (US 15 Business) and US 460 Business in Farmville north to SR 6 at Georges Tavern. SR 45 is the primary north - south highway of Cumberland County, where the highway meets US 60 near the county seat, Cumberland.
SR 45 begins at an intersection with US 15 Business and US 460 Business near the campus of Longwood University in the town of Farmville, which has portions in Prince Edward and Cumberland counties. US 15 Business heads south on Main Street and US 460 Business heads east on Third Street; the two business routes head west together on Third Street. SR 45 heads north on Main Street and intersects the High Bridge Trail, a rail trail along a former Norfolk Southern Railway line. The state highway leaves the downtown area and crosses the Appomattox River into Cumberland County. SR 45 heads northeast from the town as Cumberland Road, which passes through the small communities of Raines Tavern, Hawk, Guinea Mills, and McRae on its way to a junction with US 60 (James Anderson Highway).
SR 45 and US 60 run concurrently northeast past the county seat of Cumberland. The two highways meet the western end of SR 13 before they separate. SR 45 heads northeast as Cartersville Road through the hamlets of Ashby and Whiteville on its way to Hamilton. In Hamilton, the state highway veers east, then turns north next to the historic home Morven to head into Cartersville. SR 45 bypasses the Cartersville Historic District to the east as it descends to the James River. The state highway crosses the river immediately upstream of the ruins of the historic Cartersville Bridge. SR 45 continues through Goochland County to its northern terminus at SR 6 (River Road) at Georges Tavern.