| State: | AL |
| Type: | AL |
| Route: | 22 |
| Map Custom: | yes |
| Length Mi: | 168.543 |
| Length Round: | 3 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in Safford |
| Junction: | in Selma in Maplesville in Clanton in Rockford, Alabama in Alexander City in Roanoke |
| Terminus B: | at the Georgia state line |
| Counties: | Dallas, Chilton, Coosa, Tallapoosa, Chambers, Randolph |
| Previous Type: | I |
| Previous Route: | 22 |
| Next Type: | AL |
| Next Route: | 23 |
State Route 22 (SR 22) is a 168.5miles state highway that extends from Safford in Dallas County to the Georgia state line near Roanoke in Randolph County. The route travels across most of the state from west to east.
Starting at an intersection with SR 5 in Safford, the route travels northeast through Selma and Maplesville. At Clanton the highway is concurrent for 8miles with U.S. Route 31 (US 31), including an intersection with Interstate 65 (I-65) near the geographical center of the state. The route proceeds towards Verbena and then crosses Mitchell Lake.
The route continues east-northeast through Rockford, Alexander City, New Site and Roanoke on its way to the Georgia state line, where the road becomes Georgia State Route 34. The route is paved throughout and occasionally multi-lane. Counties traversed by the route include Dallas, Chilton, Coosa, Tallapoosa, Chambers, and Randolph.
| State: | AL |
| Type: | SR-Truck |
| Route: | 22 |
| Location: | Selma |
| Length Mi: | 3.4 |
| State: | AL |
| Type: | SR-Truck |
| Route: | 22 |
| Location: | Maplesville |
| Length Mi: | 0.3 |