| State: | FL |
| Type: | SR |
| Route: | 43 |
| Maint: | FDOT |
| Length Mi: | 41.492 |
| Length Round: | 3 |
| Established: | 1945 |
| Direction A: | South |
| Terminus A: | in Palmetto |
| Direction B: | North |
| Terminus B: | near Tampa |
| Counties: | Manatee, Hillsborough |
| Previous Type: | SR |
| Previous Route: | 41 |
| Next Type: | SR |
| Next Route: | 44 |
State Road 43 (SR 43) is the unsigned state designation for U.S. Route 301 between Palmetto and the Florida State Fairgrounds, just south of Interstate 4. Names of the road include 10th Street West in Manatee County (which includes a portion not signed as any route) and Tampa East Boulevard in Hillsborough County.
A short unsigned County Road 43 continues west from Palmetto towards Emerson Point.