| State: | IN |
| Type: | IN |
| Route: | 159 |
| Map Custom: | yes |
| Map Notes: | SR 159 highlighted in red |
| Length Mi: | 32.660 |
| Section1: | Southern segment |
| Length Mi1: | 6.084 |
| Direction A1: | South |
| Terminus A1: | in Bicknell |
| Direction B1: | North |
| Terminus B1: | in Freelandville |
| Section2: | Central segment |
| Length Mi2: | 8.103 |
| Direction A2: | South |
| Terminus A2: | CR 425 S & CR 900 E/CR 1600 W near Greene-Sullivan State Forest |
| Direction B2: | North |
| Terminus B2: | in Dugger |
| Section3: | Northern section |
| Length Mi3: | 18.473 |
| Direction A3: | South |
| Terminus A3: | near Coalmont |
| Direction B3: | North |
| Terminus B3: | in Riley |
| Counties: | Clay, Knox, Sullivan, Vigo |
| Previous Type: | IN |
| Previous Route: | 158 |
| Next Type: | IN |
| Next Route: | 160 |
State Road 159 in the U. S. state of Indiana exists in three separate sections.
The southern section begins at State Road 67 at Bicknell and ends at State Road 58 in Freelandville, 6miles to the north.
The middle section begins at Pleasantville and ends at State Road 54 at Dugger, 8miles to the north.
The northern section begins at State Road 48 at Shakamak State Park and ends at State Road 46 at Riley, 18.5miles to the north.