| State: | CO |
| Type: | CO |
| Route: | 52 |
| Map: | Colorado State Highway 52 Map.svg |
| Map Notes: | Map of northern Colorado with SH 52 highlighted in red |
| Length Mi: | 111.009 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | near Niwot |
| Junction: |
|
| Direction B: | East |
| Terminus B: | in Raymer |
| Counties: | Boulder, Weld, Morgan |
| Previous Type: | US |
| Previous Route: | 50 |
| Next Type: | CO |
| Next Route: | 53 |
State Highway 52 (SH 52) is a 1111NaN1 long state highway in northeastern Colorado. The western terminus is at SH 119 near Niwot, and the eastern terminus is at SH 14 in Raymer.
SH 52 begins near Niwot, running east from its western terminus past US 287 to a diamond interchange with I-25, near the towns of Dacono, Frederick, and Firestone. The highway continues east through interchanges with US 85 in Fort Lupton and I-76 in Hudson. Farther east, the route bends north about 12miles south of Wiggins where it begins its concurrency with I-76, US 6, and US 34 eastward to Fort Morgan where it again turns north and traverses to Raymer, where it ends at SH 14.