Stanley Cohen (biochemist) explained

Stanley Cohen
Birth Date:17 November 1922
Birth Place:Brooklyn, New York, U.S.
Death Place:Nashville, Tennessee, U.S.
Field:Biochemistry
Work Institutions:Vanderbilt University (1959–1999)
Washington University in St. Louis (1953–1959)
Alma Mater:University of Michigan
Oberlin College
Brooklyn College
Thesis Title:The Nitrogenous Metabolism of the Earthworm
Thesis Url:http://search.proquest.com/docview/301877727/
Thesis Year:1949
Doctoral Advisor:Howard B. Lewis[1] [2]
Known For:Nerve growth factor
Prizes:Rosenstiel Award
Louisa Gross Horwitz Prize (1983)
Albert Lasker Award for Basic Medical Research (1986)
Nobel Prize in Physiology or Medicine (1986)
Franklin Medal (1987)

Stanley Cohen (November 17, 1922 – February 5, 2020) was an American biochemist who, along with Rita Levi-Montalcini, was awarded the Nobel Prize in Physiology or Medicine in 1986 for the isolation of nerve growth factor and the discovery of epidermal growth factor. He died in February 2020 at the age of 97.[3] [4]

Early life and education

Cohen was born in Brooklyn, New York, on November 17, 1922. He was the son of Fannie (née Feitel) and Louis Cohen, a tailor.[5] [6] His parents were Jewish immigrants.[7] Cohen received his bachelor's degree in 1943 from Brooklyn College, where he had double-majored in chemistry and biology. After working as a bacteriologist at a milk processing plant to earn money, he received his Master of Arts in zoology from Oberlin College in 1945. He earned a doctorate from the department of biochemistry about the metabolism of earthworms at the University of Michigan in 1948.[8]

Career

His first academic employment was at the University of Colorado studying the metabolism of premature babies. In 1952 he moved to Washington University in St. Louis, working first in the department of radiology, learning isotope methodology, and then in the department of zoology. Working with Rita Levi-Montalcini, he isolated nerve growth factor. He later isolated a protein that could accelerate incisor eruption and eyelid opening in newborn mice,[9] which was renamed epidermal growth factor.[10] He continued research on cellular growth factors after joining the faculty of Vanderbilt University School of Medicine in 1959.

In 1999, Cohen retired from Vanderbilt University.[11]

Awards and legacy

Cohen received the Louisa Gross Horwitz Prize from Columbia University together with Rita Levi-Montalcini in 1983, the Nobel Prize in Physiology or Medicine in 1986 for the isolation of nerve growth factor and the discovery of epidermal growth factor and the National Medal of Science in 1986.[12] [13] [14] [15] His research on cellular growth factors has proven fundamental to understanding the development of cancer and designing anti-cancer drugs.

His Scopus h-index value was 82 as of March 2022.[16]

See also

External links

Notes and References

  1. Cohen . S. . Stanley Cohen (biochemist). Lewis . H. B. . The nitrogenous metabolism of the earthworm (Lumbricus terrestris) . The Journal of Biological Chemistry . 180 . 1 . 79–91 . 1949 . 10.1016/S0021-9258(18)56725-9 . 18133376. free .
  2. Cohen . S. . Stanley Cohen (biochemist). Lewis . H. B. . The nitrogenous metabolism of the earthworm (Lumbricus terrestric). II. Arginase and urea synthesis . The Journal of Biological Chemistry . 184 . 2 . 479–484 . 1950 . 10.1016/S0021-9258(19)50977-2 . 15428427. free .
  3. Web site: Biochemist and Nobel Prize winner Stanley Cohen dies in Nashville at age 97.
  4. News: Stanley Cohen, Nobelist, Dies at 97; Made Breakthrough on Cell Growth. The New York Times. 7 February 2020. Glaser. Vicki.
  5. Book: Stanley Cohen Biography. www.bookrags.com. 6 May 2018. live. https://web.archive.org/web/20171117070149/http://www.bookrags.com/biography/stanley-cohen-woh/. 17 November 2017.
  6. Book: Sleeman. Elizabeth. The international who's who 2004.. 2003. Europa. London. 978-1857432176. 339. 67th. 4 May 2016.
  7. Book: Nobel Laureates in Medicine or Physiology: A Biographical Dictionary. 9780429665035. Fox. Daniel M.. Meldrum. Marcia. Rezak. Ira. 2019-01-15. Routledge .
  8. Web site: The Nobel Prize in Physiology or Medicine 1986 . 2024-02-17 . NobelPrize.org . en-US.
  9. Watts . Geoff . March 2020 . Stanley Cohen . The Lancet . en . 395 . 10227 . 864 . 10.1016/S0140-6736(20)30550-X. free .
  10. Carpenter . G. . Cohen . S. . Stanley Cohen (biochemist). 10.1146/annurev.bi.48.070179.001205 . Epidermal Growth Factor . Annual Review of Biochemistry . 48 . 193–216 . 1979 . 382984.
  11. Web site: Cohen's visit brings alive wonder, power of science (12/7/07). www.mc.vanderbilt.edu. 2019-11-17. 2020-07-28. https://web.archive.org/web/20200728162826/https://www.mc.vanderbilt.edu/reporter/index.html?ID=6020. dead.
  12. Book: Cohen, Stanley. Tore Frängsmyr . Jan Lindsten. Epidermal Growth Factor. http://nobelprize.org/nobel_prizes/medicine/laureates/1986/cohen-lecture.pdf. Nobel Lectures, Physiology or Medicine 1981–1990. World Scientific Publishing Co. Singapore. 1993. 978-981-02-0793-9. live. https://web.archive.org/web/20101215042021/http://nobelprize.org/nobel_prizes/medicine/laureates/1986/cohen-lecture.pdf. 2010-12-15. Cohen's Nobel Lecture.
  13. 10.1016/S0140-6736(00)82069-3 . Raju . T. N. . The Nobel chronicles. 1986: Stanley Cohen Cohen (b 1922); Rita Levi-Montalcini (b 1909) . Lancet . 355 . 9202 . 506 . 2000 . 10841166. 54340580 .
  14. Shampo . M. A. . Kyle . R. A. . 10.4065/74.6.600 . Stanley Cohen—Nobel Laureate for Growth Factor . Mayo Clinic Proceedings . 74 . 6 . 600 . 1999 . 10377936 . free .
  15. 10.2500/108854187779045385 . Weltman . J. K. . The 1986 Nobel Prize for Physiology or Medicine awarded for discovery of growth factors: Rita Levi-Montalcini, M.D., and Stanley Cohen, Ph.D . New England and Regional Allergy Proceedings . 8 . 1 . 47–48 . 1987 . 3302667.
  16. Web site: Cohen, Stanley N.. 1 March 2020.