Stanley Plotkin Explained

Stanley Alan Plotkin
Birth Date:12 May 1932
Birth Place:New York City, U.S.
Alma Mater:SUNY Downstate Medical Center
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Known For:Vaccinology, immunology
Spouse:Susan Plotkin
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Children:2

Stanley Alan Plotkin (born May 12, 1932[1]) is an American physician who works as a consultant to vaccine manufacturers, such as Sanofi Pasteur, as well as biotechnology firms, non-profits and governments. In the 1960s, he played a pivotal role in discovery of a vaccine against rubella virus while working at Wistar Institute in Philadelphia. Plotkin was a member of Wistar’s active research faculty from 1960 to 1991. Today, in addition to his emeritus appointment at Wistar, he is emeritus professor of Pediatrics at the University of Pennsylvania. His book, Vaccines,[2] [3] is the standard reference on the subject.[4] [5] He is an editor with Clinical and Vaccine Immunology, which is published by the American Society for Microbiology in Washington, D.C.

Early life and education

Plotkin was born and raised in New York City, the son of Jewish parents, Lee and Joseph Plotkin, who emigrated from England. He attended The Bronx High School of Science in New York City. While attending Bronx Science, at the age of 15, he read a pair of books that greatly influenced his future education and career choices: Arrowsmith by Sinclair Lewis and Microbe Hunters by Paul de Kruif. Deciding to dedicate his life to being a physician and research scientist, Plotkin graduated from Bronx Science in 1948. He then earned his bachelor's degree from New York University in 1952 and went on to earn his MD at SUNY Downstate Medical Center in 1956.[6] Plotkin received his GME from the School of Medicine, University of Pennsylvania in 1963.[7]

Career

The Wistar Institute of Anatomy and Biology

During his time at Wistar, Plotkin worked on several vaccines; chief among them are vaccines for rubella, rabies, rotavirus, and cytomegalovirus (CMV). He developed a vaccine for rubella, based upon the RA 27/3 strain of the virus (also developed by Plotkin using WI-38, a fetal-derived human cell line), which was released to the public in 1969. The enabling technology was the WI-38 cell strain gifted to Plotkin by Leonard Hayflick also of the Wistar. WI-38 provide the key elements for the successful Rubella vaccine. The virus became attenuated when grown on WI-38; it was free of unwanted viruses and the vaccine proved to have minor side effects when compared with the HPV vaccine developed at the NIH. This WI-38 grown vaccine led to the eradication of the disease in the United States, according to the Centers for Disease Control and Prevention, in 2005.[8] Plotkin, working with Tadeusz Wiktor and Hilary Koprowski, produced a human vaccine for rabies during the 1960s and 1970s also on the WI-38 cell strain gifted to them by Leonard Hayflick. WI-38 provided to the rabies vaccine the same properties that it gave to the rubella vaccine. This rabies vaccine can be used as a preventive measure for people who have an increased risk of contracting rabies, as well as a treatment for those who have been exposed recently to the disease, preventing infection in nearly 100 percent of cases. Another vaccine that Plotkin co-developed, working with H. Fred Clark and Paul Offit, is for rotavirus. In 2006, the team's vaccine became part of the U.S. recommended vaccine schedule for babies. In the 1970s, Plotkin led the development of an experimental vaccine against CMV. This vaccine, developed using attenuated CMV, has yet to make it into commercial production.

Other positions held

Awards

Personal life

Plotkin and his wife, Susan, have two children, Michael and Alec. In 1957, Plotkin wanted to join the US Air Force so that he could learn to fly, but instead he went to work for the Epidemic Intelligence Service. He eventually realized his dream of learning to fly at the age of 74.

Selected publications

External links

Notes and References

  1. Web site: Brasil, Cartões de Imigração, 1961: Stanley Alan Plotkin. FamilySearch.
  2. Book: Plotkin. Stanley A. Orenstein. Walter A. Vaccines. 2004. Saunders. Philadelphia, Pa.. 0721696880. 51811284. en.
  3. Book: Orenstein. Stanley. Stanley A. Plotkin, Walter A.. Vaccines. 1999. W.B. Saunders Co. Philadelphia. 0721674437. 3rd. Smallpox and Vaccinia.
  4. Web site: Dr. Stanley Plotkin talks CMV vaccine research. National CMV Foundation. 9 August 2017.
  5. Web site: Christian H. Ross. Stanley Alan Plotkin (1932-). The Embryo Project Encyclopedia. 14 Aug 2017. https://web.archive.org/web/20170814200114/https://embryo.asu.edu/pages/stanley-alan-plotkin-1932. 14 August 2017. 13 Apr 2017.
  6. Web site: Stanley A. Plotkin, MD. National Foundation for Infectious Diseases. 9 August 2017.
  7. Web site: PENN MED SPRING 2002. University of Pennsylvania Medical Center. 6 October 2017. 29. PDF.
  8. Web site: History. Wistar. 4 August 2017.
  9. Book: Nemeh. Katherine H.. American Men & Women of Science: A Biographical Directory of Today's Leaders in Physical, Biological and Related Sciences. 2014. 978-1414497181. 1434. 32nd.
  10. Web site: Plotkin, MD. Agence de Médecine Préventive. 14 Aug 2017. https://web.archive.org/web/20170814211430/http://amp-vaccinology.org/team/stanley-plotkin. 14 August 2017.
  11. Web site: Florence Pat Haseltine. Florence Pat Haseltine. Prominent Virologist Stanley Plotkin Joins GVN as Senior Advisor. Global Virus Network. 14 January 2014. 14 Aug 2017. https://web.archive.org/web/20170814213156/http://gvn.org/prominent-virologist-stanley-plotkin-joins-gvn-as-senior-advisor/. 14 August 2017.
  12. Web site: Scientific Advisory Board. Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery. 14 Aug 2017. https://web.archive.org/web/20150803042846/http://chavi-id-duke.org/about-us/scientific-advisory-board. 2015-08-03. dead.
  13. Web site: Stanley A. Plotkin. Johns Hopkins Bloomberg School of Public Health. 14 Aug 2017. https://web.archive.org/web/20170814192343/https://www.jhsph.edu/faculty/directory/profile/1121/stanley-a-plotkin. 14 August 2017.
  14. Web site: About. Mymetics. 14 Aug 2017. https://web.archive.org/web/20161114163332/http://www.mymetics.com/about. 2016-11-14. dead.
  15. News: Davos launch for coalition to prevent epidemics of emerging viruses . . Clive Cookson . 18 January 2017 . 6 March 2020 . Billion-dollar programme aims to cut vaccine-development time from 12 years to one.
  16. John Cohen. 2 September 2016. New vaccine coalition aims to ward off epidemics. Science. 353. 6303.
  17. Web site: James D. Bruce Memorial Award for Distinguished Contributions in Preventive: Full Lists of Recipients. Awards, Masterships & Competitions. American College of Physicians. 5 Aug 2017. https://web.archive.org/web/20170805051721/https://www.acponline.org/system/files/documents/about_acp/awards_masterships/awards_2016.pdf. 5 August 2017.
  18. Web site: Distinguished Physician. Pediatric Infectious Diseases Society. 5 Aug 2017. https://web.archive.org/web/20170805051542/https://www.pids.org/awards/society-awards/distinguished-physician-award.html. 5 August 2017.
  19. Web site: Past Award Recipients. Pan-American Society for Clinical Virology. 5 Aug 2017. https://web.archive.org/web/20170805050652/http://www.pascv.org/?page=PastAwards. 5 August 2017.
  20. Web site: Dr. Plotkin receives French award for role in developing vaccines. AAP News & Journals Gateway. 14 Aug 2017. https://web.archive.org/web/20170814023058/http://www.aappublications.org/content/14/8/26.2?sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token. 14 August 2017. 1 Aug 1998.
  21. Web site: The Albert B. Sabin Gold Medal Award. Sabin. 5 Aug 2017. https://web.archive.org/web/20170805051157/http://www.sabin.org/sabin-gold-medal-award. 5 August 2017.
  22. Web site: Wistar Emeritus Professor Stanley A. Plotkin, M.D., Elected to Institute of Medicine. Wistar. 4 August 2017. https://web.archive.org/web/20130513092738/https://www.wistar.org/news-and-media/press-releases/wistar-emeritus-professor-stanley-plotkin-md-elected-institute-medicin. 13 May 2013.
  23. Web site: Distingished [sic] Graduate Award]. Perelman School of Medicine at the University of Pennsylvania. 6 October 2017.
  24. Web site: February 1, 2023 . How to Nominate for ASM Awards and Prize, Past Laureates, page 24 .
  25. Web site: Maxwell Finland Award for Scientific Achievement. National Foundation for Infectious Diseases. 9 August 2017.
  26. Web site: Ben Leach. The Wistar Gala Honors Brian H. Dovey and Stanley A. Plotkin, M.D.. Wistar. 11 November 2013 . 4 August 2017. https://web.archive.org/web/20170804020436/https://www.wistar.org/wistar-today/wistar-wire/2013-11-11/the-wistar-gala-honors-brian-h-dovey-and-stanley-plotkin-md. 4 August 2017.
  27. Web site: Dr. Stanley A. Plotkin to Receive the Hamdan Award for Medical Research Excellence in the Field of Vaccines. Wistar. 4 August 2017. https://web.archive.org/web/20151009211656/https://www.wistar.org/news-and-media/press-releases/dr-stanley-plotkin-receive-the-hamdan-award-medical-research-excellenc. 9 October 2015.
  28. Web site: Dr. Charles Mérieux Award for Achievement in Vaccinology and Immunology. National Foundation for Infectious Diseases. 29 August 1999. 14 Aug 2017. https://web.archive.org/web/20170606000510/http://www.nfid.org/awards/merieux. 6 June 2017.

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