Staci Bilbo Explained

Staci Bilbo
Nationality:American
Fields:Neuroimmunology
Workplaces:Duke University
Alma Mater:B.A. University of Texas at Austin, M.A. and Ph.D. Johns Hopkins University, Postdoctoral work University of Colorado
Known For:Neonatal infection primes microglia

Staci Bilbo is an American neuroimmunologist and The Haley Family Professor of Psychology and Neuroscience at Duke University. Bilbo also holds a position as a research affiliate at Massachusetts General Hospital overseeing research within the Lurie Center for Autism. As the principal investigator of the Bilbo Lab, Bilbo investigates how environmental challenges during the perinatal period impact the immune system and further influence brain development, cognition, and affective behaviors later in life..

Education

Bilbo completed her undergraduate degree in psychology and biology at the University of Texas at Austin.[1] She received her Bachelor of Arts in 1998, graduating with high honors. While Bilbo was at UT Austin, she conducted research on the role of the cholinergic system in learning in frogs.[2]

After her undergraduate degree, Bilbo joined the lab of Randy Nelson at Johns Hopkins University.[3] Bilbo completed her master's degree in 2000 and continued on to complete a PhD in Neuroendocrinology in Nelson's lab.  

Bilbo's graduate work was largely involving the importance of social and environmental factors in the regulation of sex specific and seasonal changes in immune response. She published a paper how immune signalling influenced partner preferences in prairie voles in 1999,[4] and another on how sex hormones impact immune function in male and female Siberian Hamsters in 2001.[5] In 2002, Bilbo published a first author paper in the Proceedings of the Royal Society showing the effect of shortening photoperiods on the immune response of Siberian hamsters.[6] Following this finding, Bilbo explored how photoperiods predict environmental conditions and immune trafficking in anticipation of infection.[7] In 2002 Bilbo published a paper on the importance of melatonin in regulating immune response.[8] In 2003, Bilbo published a paper on the sex differences in immune responses to photoperiod modulation.[9]

Career and research

After completing her graduate work, Bilbo pursued her postdoctoral work in neuroimmunology at the Center for Neuroscience at the University of Colorado in 2003. Her research work here was concerned with the effects of neonatal bacterial infection on memory impairment in adult rats.[10] [11] [12] [13] In 2007, Bilbo was appointed to assistant professor of psychology and neuroscience at Duke University.[14] Bilbo remained on the faculty at Duke, leading the Developmental Neuroimmunology Lab until 2016.[15] During her time at Duke, Bilbo investigated neuroimmune interactions in brain development,[16] and the effect of neonatal infection on glial cell biology and immune functions later in life.[17] [18]

In 2016, Bilbo joined the faculty at Harvard Medical School and became the Lurie Family Associate Professor of Pediatric and Neuroscience as well as the director of research for the Lurie Center for Autism at the Massachusetts General Hospital for Children. During this time she did research on the effect of adolescent exposure to morphine on long-term microglial gene expression.[19] [20] She also studied the effect of environmental pollutant exposure during critical periods of prenatal development on metabolic, behavioral, and neuroinflammatory developments in adult offspring.[21] [22] In 2018, Bilbo and her lab studied the role of microglia in the regulation of social behavior in adolescent rats.[23] Following these findings, Bilbo wrote a review paper highlighting the understudied connections between the immune system, social behavior, and dopaminergic circuitry.[24]

Bilbo returned to Duke in July 2019 to hold the title of Haley Family Professor of Psychology and Neuroscience while still collaborating with the Lurie Center and other researchers in Boston.

Bilbo remains active in the scientific community as an editorial board member for Brain, Behavior, and Immunity, an invited journal editor for Brain, Behavior, and Immunity, and as a previous guest editor for Hormones and Behavior.[25]  Bilbo is also actively involved in outreach in the Duke community and recently gave a talk geared towards raising the visibility of female scientists and to encourage female participation in STEM.[26]

Awards and honors

Select publications

Notes and References

  1. Web site: Staci D. Bilbo Duke Psychology & Neuroscience. psychandneuro.duke.edu. en. 2020-04-11.
  2. Bilbo. Staci D. Day. Lainy B. Wilczynski. Walter. 2000-05-01. Anticholinergic effects in frogs in a Morris water maze analog. Physiology & Behavior. en. 69. 3. 351–357. 10.1016/S0031-9384(99)00251-6. 10869602. 1147261. 0031-9384.
  3. Web site: Lurie Center Welcomes Director of Research: Staci Bilbo. Massachusetts General Hospital. en. 2020-04-11.
  4. Bilbo. Staci D.. Klein. Sabra L.. DeVries. A. Courtney. Nelson. Randy J.. 1999-12-01. Lipopolysaccharide facilitates partner preference behaviors in female prairie voles. Physiology & Behavior. en. 68. 1. 151–156. 10.1016/S0031-9384(99)00154-7. 10627074. 9470068. 0031-9384.
  5. Bilbo. S. D.. Nelson. R. J.. January 2001. Sex steroid hormones enhance immune function in male and female Siberian hamsters. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 280. 1. R207–213. 10.1152/ajpregu.2001.280.1.R207. 0363-6119. 11124153. 38195060 .
  6. Bilbo. Staci D.. Drazen. Deborah L.. Quan. Ning. He. Lingli. Nelson. Randy J.. 2002-03-07. Short day lengths attenuate the symptoms of infection in Siberian hamsters. Proceedings of the Royal Society of London. Series B: Biological Sciences. 269. 1490. 447–454. 10.1098/rspb.2001.1915. 1690914. 11886635.
  7. Bilbo. Staci D.. Dhabhar. Firdaus S.. Viswanathan. Kavitha. Saul. Alison. Yellon. Steven M.. Nelson. Randy J.. 2002-03-19. Short day lengths augment stress-induced leukocyte trafficking and stress-induced enhancement of skin immune function. Proceedings of the National Academy of Sciences. en. 99. 6. 4067–4072. 10.1073/pnas.062001899. 0027-8424. 11904451. 122649. 2002PNAS...99.4067B. free.
  8. Bilbo. Staci D.. Nelson. Randy J.. 2002-07-01. Melatonin Regulates Energy Balance and Attenuates Fever in Siberian Hamsters. Endocrinology. en. 143. 7. 2527–2533. 10.1210/endo.143.7.8922. 12072384. 0013-7227. free.
  9. Bilbo. S. D.. Dhabhar. F. S.. Viswanathan. K.. Saul. A.. Nelson. R. J.. 2003-11-01. Photoperiod affects the expression of sex and species differences in leukocyte number and leukocyte trafficking in congeneric hamsters. Psychoneuroendocrinology. en. 28. 8. 1027–1043. 10.1016/S0306-4530(02)00122-1. 14529706. 32316. 0306-4530.
  10. Web site: Bilbo Lab. Bilbo Lab. en-US. 2020-04-11.
  11. Bilbo. Staci D.. Rudy. Jerry W.. Watkins. Linda R.. Maier. Steven F.. 2006-04-25. A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behavioural Brain Research. en. 169. 1. 39–47. 10.1016/j.bbr.2005.12.002. 16413067. 41934647. 0166-4328.
  12. Bilbo. Staci D.. Barrientos. Ruth M.. Eads. Andrea S.. Northcutt. Alexis. Watkins. Linda R.. Rudy. Jerry W.. Maier. Steven F.. 2008-05-01. Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood. Brain, Behavior, and Immunity. en. 22. 4. 451–455. 10.1016/j.bbi.2007.10.003. 17997277. 24114395. 0889-1591.
  13. Bilbo. Staci D.. Yirmiya. Raz. Amat. Jose. Paul. Evan D.. Watkins. Linda R.. Maier. Steven F.. 2008-04-01. Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology. en. 33. 3. 261–269. 10.1016/j.psyneuen.2007.11.008. 18164556. 0306-4530. 2274778.
  14. Web site: Staci Bilbo wins Neuroscience Award. today.duke.edu. 8 September 2011 . en. 2020-04-11.
  15. Web site: Staci Bilbo, Ph.D. Innovation Center on Sex Differences in Medicine. en-US. 2020-04-11.
  16. Schwarz. Jaclyn M.. Sholar. Paige W.. Bilbo. Staci D.. 2012. Sex differences in microglial colonization of the developing rat brain. Journal of Neurochemistry. en. 120. 6. 948–963. 10.1111/j.1471-4159.2011.07630.x. 1471-4159. 3296888. 22182318.
  17. Bland. Sondra T.. Beckley. Jacob T.. Watkins. Linda R.. Maier. Steven F.. Bilbo. Staci D.. 2010-04-19. Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. Neuroscience Letters. en. 474. 1. 52–57. 10.1016/j.neulet.2010.03.006. 20223277. 0304-3940. 2865898.
  18. Williamson. Lauren L.. Sholar. Paige W.. Mistry. Rishi S.. Smith. Susan H.. Bilbo. Staci D.. 2011-10-26. Microglia and Memory: Modulation by Early-Life Infection. Journal of Neuroscience. en. 31. 43. 15511–15521. 10.1523/JNEUROSCI.3688-11.2011. 0270-6474. 22031897. 3224817. free.
  19. Schwarz. Jaclyn M.. Bilbo. Staci D.. 2013-01-16. Adolescent Morphine Exposure Affects Long-Term Microglial Function and Later-Life Relapse Liability in a Model of Addiction. Journal of Neuroscience. en. 33. 3. 961–971. 10.1523/JNEUROSCI.2516-12.2013. 0270-6474. 23325235. 3713715. free.
  20. Lacagnina. Michael J.. Kopec. Ashley M.. Cox. Stewart S.. Hanamsagar. Richa. Wells. Corinne. Slade. Susan. Grace. Peter M.. Watkins. Linda R.. Levin. Edward D.. Bilbo. Staci D.. October 2017. Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. Neuropsychopharmacology. en. 42. 11. 2128–2140. 10.1038/npp.2017.82. 28436446. 5603817. 1740-634X. free.
  21. Bolton. Jessica L.. Auten. Richard L.. Bilbo. Staci D.. 2014-03-01. Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. Brain, Behavior, and Immunity. en. 37. 30–44. 10.1016/j.bbi.2013.10.029. 24184474. 28164481. 0889-1591.
  22. Bolton. Jessica L.. Marinero. Steven. Hassanzadeh. Tania. Natesan. Divya. Le. Dominic. Belliveau. Christine. Mason. S. N.. Auten. Richard L.. Bilbo. Staci D.. 2017. Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner. Frontiers in Synaptic Neuroscience. English. 9. 10. 10.3389/fnsyn.2017.00010. 28620294. 5449437. 1663-3563. free.
  23. Kopec. Ashley M.. Smith. Caroline J.. Ayre. Nathan R.. Sweat. Sean C.. Bilbo. Staci D.. 2018-09-25. Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. Nature Communications. en. 9. 1. 3769. 10.1038/s41467-018-06118-z. 30254300. 6156594. 2018NatCo...9.3769K. 2041-1723. free.
  24. Kopec. Ashley M.. Smith. Caroline J.. Bilbo. Staci D.. 2019-05-01. Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?. Trends in Neurosciences. English. 42. 5. 337–348. 10.1016/j.tins.2019.02.005. 0166-2236. 30890276. 6486862.
  25. Web site: Microglia - Brain's first responders. Dana Foundation Podcast Transcript. April 10, 2020.
  26. Web site: A Day of STEM for Girls. 2020-03-10. Research Blog. en-US. 2020-04-11.
  27. Web site: Bass Connections Team Leader. Brain and Society Theme. Scholars@Duke. scholars.duke.edu. 2020-04-11.
  28. Web site: Glenn Hatton Lecture. Center for Glial-Neuronal Interactions. en. 2020-04-11.
  29. Web site: Frank Beach Young Investigator Award. Society for Behavioral Neuroendocrinology. Scholars@Duke. scholars.duke.edu. 2020-04-11.
  30. Web site: Robert Ader New Investigator Award. PsychoNeuroImmunology Research Society. Scholars@Duke. scholars.duke.edu. 2020-04-11.
  31. Web site: DIBS Research Incubator Award. Duke Institute for Brain Sciences. Scholars@Duke. scholars.duke.edu. 2020-04-11.
  32. Web site: Staci Bilbo Harvard Catalyst Profiles Harvard Catalyst. connects.catalyst.harvard.edu. 2020-04-11.

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