| Saint-Macaire | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Saint-Macaire (Gironde).svg |
| Arrondissement: | Langon |
| Canton: | L'Entre-Deux-Mers |
| Insee: | 33435 |
| Postal Code: | 33490 |
| Mayor: | Cédric Gerbeau[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 44.5675°N -0.2225°W |
| Elevation M: | 12 |
| Elevation Min M: | 0 |
| Elevation Max M: | 30 |
| Area Km2: | 1.79 |
Saint-Macaire (in French pronounced as /sɛ̃ makɛʁ/; Occitan (post 1500);: Sent Macari) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France. It is the site of the Château de Tardes. Saint-Macaire station has rail connections to Agen, Langon and Bordeaux.