| St. Regis River | |
| Pushpin Map: | United States |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States and Canada |
| Subdivision Type2: | State and province |
| Subdivision Name2: | New York and Quebec |
| Subdivision Type3: | Administrative region (QC) |
| Subdivision Name3: | Montérégie (QC) |
| Subdivision Type4: | MRC (QC) |
| Subdivision Name4: | Le Haut-Saint-Laurent Regional County Municipality (QC) |
| Subdivision Name5: | Akwesasne |
| Length: | 86miles |
| Mouth: | Saint Lawrence River |
| Mouth Location: | Saint Regis, New York, Franklin County |
| Mouth Coordinates: | 44.9995°N -74.6412°W |
| Mouth Elevation: | NaNurl = https://waterdata.usgs.gov/nwis/inventory/?site_no=0426950803&agency_cd=USGS& |
| Basin Size: | 860sqmi |
The St. Regis River (or rivière Saint-Régis in Quebec) is an 86adj=midNaNadj=mid[1] river in northern New York in the United States. It flows into the Saint Lawrence River at the hamlet of Saint Regis in the St. Regis Mohawk Reservation. The Saint Regis River basin includes Upper and Lower St. Regis Lakes, and Saint Regis Pond in the Saint Regis Canoe Area. It's a great fishery for trout.
The toponym "rivière Saint-Régis" was made official on December 5, 1968 at the Commission de toponymie du Québec.[2]