| Image Coa: | COA St Leon-Rot.svg |
| Coordinates: | 49.2653°N 8.5986°W |
| Image Plan: | St. Leon-Rot in HD.svg |
| State: | Baden-Württemberg |
| Region: | Karlsruhe |
| District: | Rhein-Neckar-Kreis |
| Elevation: | 107 |
| Area: | 25.56 |
| Postal Code: | 68789 |
| Area Code: | 06227 |
| Licence: | HD |
| Gemeindeschlüssel: | 08 2 26 103 |
| Website: | www.st-leon-rot.de |
| Mayor: | Alexander Eger[1] |
| Leader Term: | 2022 - 30 |
Sankt Leon-Rot is a municipality in the district of Rhein-Neckar-Kreis, in Baden-Württemberg, Germany. It is situated 16 km south of Heidelberg.
Sankt Leon-Rot is located in the Kraichbach lowlands, belonging to the Upper Rhine Graben. It is part of the Rhine-Neckar metropolitan region.