| Official Name: | St. Johnsbury, Vermont |
| Settlement Type: | Census-designated place |
| Pushpin Map: | Vermont#USA |
| Pushpin Label: | St. Johnsbury |
| Pushpin Label Position: | left |
| Coordinates: | 44.4192°N -72.0153°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Vermont |
| Subdivision Type2: | County |
| Subdivision Name2: | Caledonia |
| Subdivision Type3: | Town |
| Subdivision Name3: | St. Johnsbury |
| Area Footnotes: | [1] |
| Area Total Km2: | 33.8 |
| Area Land Km2: | 33.2 |
| Area Water Km2: | 0.6 |
| Population As Of: | 2020 |
| Population Footnotes: | [2] |
| Population: | 5994 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation M: | 183 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 05819 |
| Area Code: | 802 |
| Blank Name: | FIPS code |
| Blank Info: | 50-62125 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2378133 |
St. Johnsbury is a census-designated place (CDP) corresponding to the main settled areas in the town of St. Johnsbury, Caledonia County, Vermont, United States. As of the 2020 census it had a population of 5,994,[2] out of 7,364 in the entire town.
The CDP is in eastern Caledonia County, occupying the southern one-third of the town of St. Johnsbury. It includes the urban center of St. Johnsbury, the village of St. Johnsbury Center to the north up the valley of the Passumpsic River, and development along Route 2 to the east up the valley of the Moose River, but not as far as the village of East St. Johnsbury.
Interstate 91 passes through the west side of the CDP, with access from Exits 20, 21, and 22. I-91 leads north to Newport and south to White River. U.S. Routes 2 and 5 intersect in the center of the community. U.S. 2 leads west to Montpelier, the state capital, and east to Lancaster, New Hampshire, while U.S. 5 provides a local parallel route to I-91, leading north 8miles to Lyndonville and south to Wells River.