| St. Joe, Illinois | |
| Settlement Type: | Unincorporated community |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Illinois |
| Subdivision Type2: | County |
| Subdivision Name2: | Monroe |
| Subdivision Type3: | Precinct |
| Subdivision Name3: | 23 |
| Pushpin Map: | Illinois#USA |
| Pushpin Label: | St. Joe |
| Coordinates: | 38.2328°N -90.1536°W |
| Elevation Ft: | 705 |
| Population Density Km2: | auto |
| Timezone1: | CST |
| Utc Offset1: | -6 |
| Timezone1 Dst: | CDT |
| Utc Offset1 Dst: | -5 |
| Postal Code Type: | Postal code |
| Postal Code: | 62298 |
| Area Code: | 618 |
St. Joe, Illinois is a small unincorporated community in the historic New Design Precinct of Monroe County, Illinois, United States. It is located along the historic road from Kaskaskia to St. Louis, between Renault and Burksville.