| St. James A. M. E. Church | |
| Coordinates: | 28.8044°N -81.2639°W |
| Architecture: | Gothic Revival, Other |
| Built: | 1913 |
| Added: | April 24, 1992 |
| Refnum: | 92000352 |
St. James A. M. E. Church is a congregation of the African Methodist Episcopal Church in Sanford, Florida, United States. The oldest church in Sanford founded by African Americans, it was established in 1867, when the church purchased land on the corner of East Ninth Street and South Cypress Avenue.
The original church building was replaced in 1913 with a red brick Gothic Revival building designed by local architect Prince W. Spears.
In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press.[1] On April 24, 1992, it was added to the U.S. National Register of Historic Places.