| St. Francis DeSales Roman Catholic Church | |
| Location: | 116 S. 6th St. Paducah, Kentucky |
| Coordinates: | 37.0856°N -88.6°W |
| Built: | 1899 |
| Added: | April 16, 1979 |
| Area: | 0.8acres |
| Refnum: | 79003119 |
The St. Francis DeSales Roman Catholic Church (Church of St. Francis de Sales) is a historic church building at 116 S. 6th Street in Paducah, Kentucky. It was built in 1899 and, together with its 1927-built rectory, was added to the National Register of Historic Places in 1979.
It is a Classical Revival-style building named for St. Francis de Sales.[1]