| Official Name: | St. Charles, South Carolina |
| Settlement Type: | Census-designated place |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | St. Charles |
| Coordinates: | 34.0694°N -80.2197°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Lee |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 4.24 |
| Area Land Sq Mi: | 4.24 |
| Area Water Sq Mi: | 0.00 |
| Area Total Km2: | 10.97 |
| Area Land Km2: | 10.97 |
| Area Water Km2: | 0.00 |
| Population As Of: | 2020 |
| Population Density Km2: | 10.39 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 172 |
| Postal Code Type: | ZIP Codes |
| Postal Code: | 29010 (Bishopville) 29104 (Mayesville) |
| Area Code: | 803/839 |
| Blank Name: | FIPS code |
| Blank Info: | 45-62485 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2807067 |
| Population Total: | 114 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 26.92 |
St. Charles is an unincorporated community and census-designated place (CDP) in Lee County, South Carolina, United States. It was first listed as a CDP prior to the 2020 census with a population of 114.[2]
The CDP is in southern Lee County, at the junction of U.S. Route 401 and South Carolina Highway 154. Highway 401 leads northeast to Darlington and southwest to Sumter, while Highway 154 leads north to Bishopville and south 6miles to Mayesville.
| White alone (NH) | 49 | 42.98% | |
| Black or African American alone (NH) | 59 | 51.75% | |
| Native American or Alaska Native alone (NH) | 0 | 0.00% | |
| Asian alone (NH) | 0 | 0.00% | |
| Pacific Islander alone (NH) | 0 | 0.00% | |
| Some Other Race alone (NH) | 0 | 0.00% | |
| Mixed Race/Multi-Racial (NH) | 3 | 2.63% | |
| Hispanic or Latino (any race) | 3 | 2.63% | |
| Total | 114 | 100.00% |