SroB RNA explained

sroB RNA
Symbol:	sroB
Rfam:	RF00368
Rna Type:	Gene sRNA
Tax Domain:	Bacteria

The sroB RNA (also known as MicM, rybC, or ChiX) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species but its function is unknown.^{[1] [2]} SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes. SroB is expressed in stationary phase.Experiments have shown that SroB is a Hfq binding sRNA.^[3]

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction.^[4] SroB also regulates the DpiA/DpiB two-component system.^[5] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chbBC intergenic region.^{[6] [7] [8]}

Further reading

• Plumbridge J, Bossi L, Oberto J, Wade JT, Figueroa-Bossi N . Interplay of transcriptional and small RNA-dependent control mechanisms regulates chitosugar uptake in Escherichia coli and Salmonella.. Molecular Microbiology. March 5, 2014. 24593230 . 10.1111/mmi.12573 . 92 . 4 . 648–658. 25492913. free.

Notes and References

1. Vogel J, Bartels V, Tang TH, etal . RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria . Nucleic Acids Res. . 31 . 22 . 6435–6443 . 2003 . 14602901 . 10.1093/nar/gkg867 . 275561 .
2. Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S . Global analysis of small RNA and mRNA targets of Hfq . Mol. Microbiol. . 50 . 4 . 1111–1124 . November 2003 . 14622403 . 10.1046/j.1365-2958.2003.03734.x. 40056275 . free .
3. Sittka A, Lucchini S, Papenfort K, etal . Burkholder . William F. . Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq . PLOS Genet. . 4 . 8 . e1000163 . 2008 . 18725932 . 2515195 . 10.1371/journal.pgen.1000163 . free .
4. Rasmussen AA, Johansen J, Nielsen JS, Overgaard M, Kallipolitis B, Valentin-Hansen P . A conserved small RNA promotes silencing of the outer membrane protein YbfM . Mol. Microbiol. . 72. 3. 566–577. April 2009 . 19400782 . 10.1111/j.1365-2958.2009.06688.x . 24575908 .
5. Mandin . P. . Gottesman . S. . 10.1111/j.1365-2958.2009.06665.x . A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system . Molecular Microbiology . 72 . 3 . 551–565 . 2009 . 19426207 . 2714224 .
6. Overgaard M, Johansen J, Møller-Jensen J, Valentin-Hansen P . Switching off small RNA regulation with trap-mRNA. . Mol Microbiol . 73 . 5 . 790–800 . 2009 . 19682266 . 10.1111/j.1365-2958.2009.06807.x. free .
7. Vogel J . An RNA trap helps bacteria get the most out of chitosugars . Mol. Microbiol. . 73. 5. 737–741. July 2009 . 19659640 . 10.1111/j.1365-2958.2009.06806.x . 26358452 . https://archive.today/20130105073617/http://www3.interscience.wiley.com/resolve/doi/abs?DOI=10.1111/j.1365-2958.2009.06806.x. dead. 2013-01-05.
8. Figueroa-Bossi N, Valentini M, Malleret L, Fiorini F, Bossi L . Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target. . Genes Dev . 23 . 17 . 2004–2015 . 2009 . 19638370 . 10.1101/gad.541609 . 2751969.