SraL RNA explained

The SraL RNA ('sra' for small RNA), also known as RyjA, is a small non-coding RNA discovered in E. coli,^{[1] [2]} and later in Salmonella Tiphimurium.^{[3] [4]} This ncRNA was found to be expressed only in stationary phase. It may possibly play a role in Salmonella virulence. The major stationary phase regulator RpoS is transcriptionally regulating SraL and directly binds to the sraL gene promoter. SraL down-regulates the expression of the ribosome-associated chaperone Trigger Factor (TF), which is involved in the folding of the newly synthesised cystolic proteins.^[5]

Notes and References

1. Argaman. L.. Hershberg. R.. Vogel. J.. Bejerano. G.. Wagner. E. G.. Margalit. H.. Altuvia. S.. 2001-06-26. Novel small RNA-encoding genes in the intergenic regions of Escherichia coli. Current Biology. 11. 12. 941–950. 0960-9822. 11448770. 10.1016/s0960-9822(01)00270-6. free.
2. Wassarman. K. M.. Repoila. F.. Rosenow. C.. Storz. G.. Gottesman. S.. 2001-07-01. Identification of novel small RNAs using comparative genomics and microarrays. Genes & Development. 15. 13. 1637–1651. 10.1101/gad.901001. 0890-9369. 11445539. 312727.
3. Viegas. Sandra C.. Pfeiffer. Verena. Sittka. Alexandra. Silva. Inês J.. Vogel. Jörg. Arraiano. Cecília M.. 2007. Characterization of the role of ribonucleases in Salmonella small RNA decay. Nucleic Acids Research. 35. 22. 7651–7664. 10.1093/nar/gkm916. 1362-4962. 2190706. 17982174.
4. Ortega. Alvaro D.. Gonzalo-Asensio. Jesús. García-del Portillo. Francisco. April 2012. Dynamics of Salmonella small RNA expression in non-growing bacteria located inside eukaryotic cells. RNA Biology. 9. 4. 469–488. 10.4161/rna.19317. 1555-8584. 22336761. free.
5. Silva. Inês Jesus. Ortega. Alvaro Darío. Viegas. Sandra Cristina. García-Del Portillo. Francisco. Arraiano. Cecília Maria. September 2013. An RpoS-dependent sRNA regulates the expression of a chaperone involved in protein folding. RNA. 19. 9. 1253–1265. 10.1261/rna.039537.113. 1469-9001. 3753932. 23893734.