| Squinzano | |
| Official Name: | Comune di Squinzano |
| Shield Alt: | Coat of arms of Squinzano |
| Pushpin Label Position: | left |
| Coordinates: | 40.4333°N 21°W |
| Region: | Apulia |
| Province: | Lecce (LE) |
| Frazioni: | Casalabate |
| Mayor: | Giovanni Marra |
| Area Total Km2: | 29.78 |
| Population Footnotes: | [1] |
| Population Total: | 14100 |
| Population As Of: | 1 January 2017 |
| Population Demonym: | Squinzanesi |
| Elevation M: | 48 |
| Saint: | St. Nicholas of Bari |
| Postal Code: | 73018 |
| Area Code: | 0832 |
Squinzano (Salentino: Sicilian: Schinzànu) is a town and comune in the province of Lecce in the Apulia region of south-east Italy. It is the twelfth-most populous city in the province of Lecce.
Squinzano is also a specific area within the Apulian wine region. Squinzano DOC is produced in red and rosé versions, and is obtained principally from the Negro Amaro grape, with a small addition of Malvasia Nera di Brindisi and Malvasia Nera di Lecce.[2]