SERPINB4 explained

Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.^{[1] [2] [3]}

See also

• Serpin

Further reading

• Barnes RC, Worrall DM . Identification of a novel human serpin gene; cloning sequencing and expression of leupin. . FEBS Letters . 373 . 1 . 61–5 . 1995 . 7589435 . 10.1016/0014-5793(95)01015-7. 26092255 . free . 1995FEBSL.373...61B .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bartuski AJ, Kamachi Y, Schick C . etal . A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases . Genomics . 54 . 2 . 297–306 . 1999 . 9828132 . 10.1006/geno.1998.5586.
• Sakaguchi Y, Kishi F, Murakami A . etal . Structural analysis of human SCC antigen 2 promoter . Biochim. Biophys. Acta . 1444 . 1 . 111–6 . 1999 . 9931463 . 10.1016/s0167-4781(98)00259-0.
• Cataltepe S, Gornstein ER, Schick C . etal . Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas . J. Histochem. Cytochem. . 48 . 1 . 113–22 . 2000 . 10653592 . 10.1177/002215540004800112. free .
• Luke C, Schick C, Tsu C . etal . Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage . Biochemistry . 39 . 24 . 7081–91 . 2000 . 10852705 . 10.1021/bi000050g.
• Uemura Y, Pak SC, Luke C . etal . Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells . Int. J. Cancer . 89 . 4 . 368–77 . 2000 . 10956412 . 10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. 23697095 . free .
• Hamada K, Shinomiya H, Asano Y . etal . Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter . Biochim. Biophys. Acta . 1518 . 1–2 . 124–31 . 2001 . 11267667 . 10.1016/s0167-4781(01)00174-9.
• Takeda A, Kajiya A, Iwasawa A . etal . Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis . Biol. Chem. . 383 . 7–8 . 1231–6 . 2003 . 12437110 . 10.1515/BC.2002.136. 23972588 .
• Strausberg RL, Feingold EA, Grouse LH . etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Gariboldi M, Peissel B, Fabbri A . etal . SCCA2-like serpins mediate genetic predisposition to skin tumors . Cancer Res. . 63 . 8 . 1871–5 . 2003 . 12702576 .
• Pontisso P, Calabrese F, Benvegnù L . etal . Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma . Br. J. Cancer . 90 . 4 . 833–7 . 2004 . 14970861 . 10.1038/sj.bjc.6601543 . 2410161.
• Gerhard DS, Wagner L, Feingold EA . etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Ray R, Choi M, Zhang Z . etal . Uteroglobin suppresses SCCA gene expression associated with allergic asthma . J. Biol. Chem. . 280 . 11 . 9761–4 . 2005 . 15677460 . 10.1074/jbc.C400581200. free .
• Rual JF, Venkatesan K, Hao T . etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209. 2005Natur.437.1173R . 4427026 .
• Sueoka K, Nawata S, Nakagawa T . etal . Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines . Int. J. Oncol. . 27 . 5 . 1345–53 . 2005 . 16211231 . 10.3892/ijo.27.5.1345.
• Kimura K, Wakamatsu A, Suzuki Y . etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129.
• Katagiri C, Nakanishi J, Kadoya K, Hibino T . Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase . J. Cell Biol. . 172 . 7 . 983–90 . 2006 . 16549498 . 10.1083/jcb.200508064 . 2063756.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.009

Notes and References

1. Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA . A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene . Proc Natl Acad Sci U S A . 92 . 8 . 3147–51 . May 1995 . 7724531 . 42122 . 10.1073/pnas.92.8.3147 . 1995PNAS...92.3147S . free .
2. Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K . The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1 . J Biol Chem . 279 . 7 . 5081–7 . Feb 2004 . 14630915 . 10.1074/jbc.M311585200 . free .
3. Web site: Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4.