| Spyros Matentzidis | |
| Fullname: | Spyridon Matentzidis |
| Birth Date: | 1990 7, df=yes |
| Birth Place: | Kilkis, Greece |
| Height: | 1.82m (05.97feet) |
| Position: | Center-back |
| Currentclub: | Doxa Chersou |
| Years1: | 2009–2010 |
| Clubs1: | Panthrakikos |
| Caps1: | 13 |
| Goals1: | 0 |
| Years2: | 2010–2013 |
| Clubs2: | AEK Athens |
| Caps2: | 0 |
| Goals2: | 0 |
| Years4: | 2010–2011 |
| Clubs4: | → Anagennisi Karditsa (loan) |
| Caps4: | 3 |
| Goals4: | 0 |
| Years5: | 2011–2012 |
| Clubs5: | → Diagoras (loan) |
| Caps5: | 10 |
| Goals5: | 0 |
| Years6: | 2012–2013 |
| Clubs6: | → Korinthos (loan) |
| Caps6: | 8 |
| Goals6: | 0 |
| Years7: | 2013–2015 |
| Clubs7: | Kilkisiakos |
| Years8: | 2015–2016 |
| Clubs8: | Vyzantio Kokkinochoma |
| Years9: | 2016–2019 |
| Clubs9: | Kilkisiakos |
| Years10: | 2019–2023 |
| Clubs10: | PAOK Kristonis |
| Years11: | 2023– |
| Clubs11: | Doxa Chersou |
| Club-Update: | 18 October 2024 |
Spyros Matentzidis (el|Σπύρος Ματεντζίδης; born on 23 July 1990) is a Greek footballer, currently playing as a center-back for Doxa Chersou.
Born in Kilkis, Matentzidis began playing football in 2009 at Panthrakikos.