SprX small RNA explained

SprX sRNA
Rfam:	RF02672
Tax Domain:	Bacteria

In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.^[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.^[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.^[3]

See also

• SprD

Notes and References

1. Bohn C, Rigoulay C, Chabelskaya S, Sharma CM, Marchais A, Skorski P, Borezée-Durant E, Barbet R, Jacquet E, Jacq A, Gautheret D, Felden B, Vogel J, Bouloc P . Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism . Nucleic Acids Research . 38 . 19 . 6620–36 . October 2010 . 20511587 . 2965222 . 10.1093/nar/gkq462 .
2. Eyraud A, Tattevin P, Chabelskaya S, Felden B . A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus . Nucleic Acids Research . 42 . 8 . 4892–905 . April 2014 . 24557948 . 4005690 . 10.1093/nar/gku149 .
3. Kathirvel M, Buchad H, Nair M . Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1 . Medical Microbiology and Immunology . 205 . 6 . 563–574 . December 2016 . 27438010 . 10.1007/s00430-016-0467-9 . 15284645 .