SprA1/SprA1as toxin/antitoxin system explained

The SprA1/SPrA1as toxin/antitoxin system identified in Staphylococcus aureus, belongs to the Type I system encoding toxin protein: SprA1 and antitoxin RNA: SprA1as. The SprA1as postranscriptionally regulates SprA1 encoding small membrane damaging protein PepA1.^{[1] [2]}

Notes and References

1. Sayed N, Jousselin A, Felden B . A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide . Nature Structural & Molecular Biology . 19 . 1 . 105–12 . December 2011 . 22198463 . 10.1038/nsmb.2193 . 8217681 .
2. Sayed N, Nonin-Lecomte S, Réty S, Felden B . Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module . The Journal of Biological Chemistry . 287 . 52 . 43454–63 . December 2012 . 23129767 . 3527932 . 10.1074/jbc.M112.402693 . free .